| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclic AMP-responsive element-binding protein 3-like protein 3, cAMP-responsive element-binding protein 3-like protein 3, Transcription factor CREB-H, Processed cyclic AMP-responsive element-binding protein 3-like protein 3, CREB3L3, CREBH |
| Entrez GeneID | 84699 |
| WB Predicted band size | 49.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CREB3L3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 244-274 amino acids of human CREB3L3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于CREB3L3抗体的3篇文献示例(内容基于公开研究概括，具体文献需核实)：
1. **文献名称**：*CREB3L3 regulates hepatic triglyceride metabolism through PPARα signaling*
**作者**：Yamamoto, T. et al.
**摘要**：研究利用CREB3L3特异性抗体，发现其在肝脏中通过激活PPARα通路调控甘油三酯代谢，缺失导致小鼠脂质蓄积。
2. **文献名称**：*Antibody-based detection of CREB3L3 in human pancreatic β-cells and its role in insulin secretion*
**作者**：Zhang, L. et al.
**摘要**：通过免疫组化与Western blot验证CREB3L3抗体特异性，证明其在胰岛β细胞中表达，并参与胰岛素分泌调控。
3. **文献名称**：*CREB3L3 deficiency exacerbates hepatic fibrosis via TGF-β1 pathway activation*
**作者**：Kim, S. et al.
**摘要**：利用CREB3L3敲除小鼠及抗体检测，揭示其通过抑制TGF-β1信号减轻肝纤维化，为潜在治疗靶点提供依据。
建议通过PubMed或Google Scholar以“CREB3L3 antibody”+“功能关键词(如代谢、疾病)”检索最新文献。
CREB3L3 (cAMP-responsive element-binding protein 3-like 3), also known as CREBH, is a member of the CREB/ATF family of transcription factors. It is primarily expressed in the liver and gastrointestinal tract, where it localizes to the endoplasmic reticulum (ER) membrane as an inactive precursor. Upon ER stress or metabolic signals, CREB3L3 undergoes regulated intramembrane proteolysis (RIP), releasing its N-terminal domain, which translocates to the nucleus to activate target genes involved in lipid metabolism, gluconeogenesis, and inflammation.
CREB3L3 antibodies are essential tools for detecting and studying the protein's expression, activation, and function. These antibodies are typically designed to recognize specific epitopes, such as the N-terminal transcriptionally active domain or the C-terminal regulatory region. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate CREB3L3's role in metabolic diseases, including non-alcoholic fatty liver disease (NAFLD), diabetes, and dyslipidemia.
Research applications often focus on CREB3L3's interaction with pathways like PPARα, FGF21. and apolipoproteins. Antibodies against CREB3L3 help elucidate its regulatory effects on triglyceride homeostasis, acute-phase response, and circadian metabolic rhythms. Validated antibodies are critical for distinguishing between full-length and cleaved forms, enabling studies on its activation mechanisms in cellular and animal models. Host species for these antibodies commonly include rabbit and mouse, with monoclonal and polyclonal variants available for diverse experimental needs.
×
