| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ghrelin O-acyltransferase, 231-, Membrane-bound O-acyltransferase domain-containing protein 4, O-acyltransferase domain-containing protein 4, MBOAT4, GOAT, OACT4 |
| Entrez GeneID | 619373 |
| WB Predicted band size | 49.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MBOAT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from the Central region of human MBOAT4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是为您整理的3篇关于MBOAT4抗体的模拟参考文献示例(请注意这些文献为示例性质，实际研究中请核实真实文献)：
1. **文献名称**: "Characterization of a Novel Anti-MBOAT4 Antibody for Lipid Metabolism Studies"
**作者**: Zhang L, et al.
**摘要**: 开发了一种高特异性兔源多克隆抗体，通过免疫印迹和免疫组化验证其在检测人类肝脏组织及细胞系中MBOAT4蛋白表达的应用，证实MBOAT4与甘油磷脂重塑通路的相关性。
2. **文献名称**: "MBOAT4 Expression in Colorectal Cancer: Insights from Immunohistochemical Analysis"
**作者**: Tanaka K, et al.
**摘要**: 使用商业化MBOAT4抗体对结直肠癌组织进行染色，发现MBOAT4高表达与患者预后不良相关，提示其可能通过调控脂肪酸代谢促进肿瘤进展。
3. **文献名称**: "Development of a Monoclonal Antibody Targeting the Extracellular Domain of MBOAT4 for Functional Studies"
**作者**: Müller S, et al.
**摘要**: 报道了一种靶向MBOAT4胞外结构域的小鼠单克隆抗体的制备，该抗体能特异性阻断MBOAT4酶活性，为研究其在神经退行性疾病中的脂质修饰功能提供了工具。
**提示**：实际文献可能需要通过PubMed或Web of Science以关键词"MBOAT4 AND (antibody OR immunohistochemistry)"检索。若需具体文献协助，建议提供研究背景或补充数据库访问权限。
**Background of MBOAT4 Antibody**
MBOAT4 (membrane-bound O-acyltransferase domain-containing protein 4), also known as OACT4. is a member of the membrane-bound O-acyltransferase family, which plays a role in lipid metabolism by catalyzing acyltransferase reactions. This enzyme is implicated in the transfer of fatty acyl groups to specific substrates, influencing processes like membrane composition, signaling, and energy homeostasis. MBOAT4 has been linked to metabolic disorders, neurodegenerative diseases, and cancer, though its precise biological functions remain under investigation.
Antibodies targeting MBOAT4 are essential tools for studying its expression, localization, and function in cellular and tissue contexts. These antibodies are typically developed using immunogenic peptides or recombinant protein fragments specific to conserved regions of MBOAT4. They enable detection via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes testing in knockout cell lines or tissues to confirm specificity.
Research applications of MBOAT4 antibodies focus on elucidating its role in lipid remodeling pathways, interactions with metabolic enzymes, and potential as a biomarker or therapeutic target. Commercial MBOAT4 antibodies are available from suppliers like Sigma-Aldrich, Abcam, and Thermo Fisher Scientific, often accompanied by data validating their use in specific experimental models. Ongoing studies aim to clarify its involvement in diseases like obesity, diabetes, and hepatocellular carcinoma, highlighting its emerging significance in biomedical research.
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