| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inter-alpha-trypsin inhibitor heavy chain H1, ITI heavy chain H1, ITI-HC1, Inter-alpha-inhibitor heavy chain 1, Inter-alpha-trypsin inhibitor complex component III, Serum-derived hyaluronan-associated protein, SHAP, ITIH1, IGHEP1 |
| Entrez GeneID | 3697 |
| WB Predicted band size | 101.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ITIH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-635 amino acids from the Central region of human ITIH1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ITIH1抗体的3篇参考文献的简要概括：
1. **文献名称**: *"Autoantibodies against ITIH1 in autoimmune liver diseases"*
**作者**: Tanaka A. et al.
**摘要**: 研究报道了ITIH1抗体在自身免疫性肝病(如原发性胆汁性胆管炎)中的潜在诊断价值，发现患者血清中ITIH1抗体水平升高可能与疾病活动相关。
2. **文献名称**: *"Proteomic identification of ITIH1 as a biomarker for ovarian cancer"*
**作者**: Zhang L. et al.
**摘要**: 通过蛋白质组学分析，发现ITIH1在卵巢癌组织中高表达，其抗体可用于组织染色辅助诊断，并与肿瘤转移和预后不良相关。
3. **文献名称**: *"ITIH1 modulates inflammation via hyaluronan regulation"*
**作者**: De la Motte C. et al.
**摘要**: 探讨了ITIH1在炎症反应中通过调控透明质酸代谢的作用，利用特异性抗体阻断实验证实其参与肠道炎症的病理过程。
*注：以上为示例性内容，实际文献需通过PubMed或学术数据库检索确认。若需具体文献，建议结合关键词“ITIH1 antibody”+“biomarker/disease/mechanism”进一步筛选。*
ITIH1 (Inter-alpha-trypsin inhibitor heavy chain H1) is a liver-synthesized glycoprotein belonging to the inter-alpha-trypsin inhibitor (ITI) family, which regulates extracellular matrix (ECM) stability and inflammatory responses. ITIH1 forms complexes with bikunin (a light chain) via glycosaminoglycan bridges, contributing to ECM organization by covalently binding hyaluronan. This interaction is critical for maintaining tissue integrity and modulating inflammation, wound healing, and cell migration pathways.
ITIH1 antibodies are essential tools for studying its expression, structure, and function in biological systems. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to quantify ITIH1 levels in serum or tissues, particularly in disease contexts. Altered ITIH1 expression has been linked to cancers (e.g., hepatocellular carcinoma, ovarian cancer), inflammatory disorders, and metabolic conditions, suggesting its potential as a diagnostic or prognostic biomarker.
Commercially available ITIH1 antibodies include monoclonal and polyclonal variants, often validated for specificity using knockout controls or immunoprecipitation-mass spectrometry. Researchers also employ these antibodies to explore ITIH1’s role in disease mechanisms, such as inflammation regulation or tumor metastasis. However, variability in antibody performance across experimental conditions necessitates careful validation to ensure reproducibility in studies.
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