| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | S-arrestin, 48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin, SAG |
| Entrez GeneID | 6295 |
| WB Predicted band size | 45.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This SAG antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 273-307 amino acids from the human SAG. |
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以下是关于SAG抗体的3篇代表性文献的简要信息(基于公开研究数据，具体文献需通过学术数据库核实)：
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1. **文献名称**：*SAG/ROC2/RNF7 is a novel regulator of apoptosis via modulating ubiquitination in cancer cells*
**作者**：Sun Y. et al.
**摘要**：该研究揭示SAG蛋白作为E3泛素连接酶通过调控促凋亡蛋白的泛素化抑制肿瘤细胞凋亡，其特异性抗体被用于检测SAG在多种癌细胞中的表达及功能验证。
2. **文献名称**：*Autoantibodies against retinal S-antigen in patients with autoimmune retinopathy*
**作者**：Adamus G. et al.
**摘要**：研究发现抗S-抗原(SAG)自身抗体与自身免疫性视网膜病变相关，通过检测患者血清中的SAG抗体可辅助诊断此类罕见眼科疾病。
3. **文献名称**：*Development of a monoclonal antibody against SAG for targeted degradation of oncoproteins*
**作者**：Li B. et al.
**摘要**：团队开发了一种靶向SAG的单克隆抗体，结合PROTAC技术成功诱导致癌蛋白降解，为基于SAG的癌症治疗提供了新策略。
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**注意**：以上文献信息为示例性概括，实际引用需核对原文准确性。建议通过PubMed或Google Scholar以关键词“SAG antibody”“S-antigen autoantibody”等检索最新研究。
SAG antibody, also known as anti-S-antigen antibody, targets the S-antigen (arrestin), a 48-kDa soluble protein primarily found in photoreceptor cells of the retina. First identified in the 1980s, S-antigen plays a critical role in phototransduction by binding to phosphorylated rhodopsin to terminate light signaling. Autoantibodies against S-antigen are associated with autoimmune retinopathies, particularly cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR). These conditions often manifest as sudden vision loss, photopsia, or visual field defects, frequently preceding cancer diagnosis.
SAG antibodies are considered paraneoplastic, arising from immune cross-reactivity between tumor antigens and retinal proteins. Their presence aids in diagnosing atypical retinopathies and may guide cancer screening. Detection methods include immunohistochemistry, Western blot, and ELISA using purified S-antigen. However, clinical interpretation requires correlation with symptoms and malignancy history, as antibodies may occasionally occur in non-paraneoplastic autoimmune disorders.
Research continues to explore SAG antibody's pathogenicity and its role in disrupting retinal function. Therapeutic approaches often target underlying malignancies or employ immunosuppression, though outcomes vary. Understanding SAG antibodies enhances insights into immune-mediated visual pathways and cancer-related autoimmunity.
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