| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Myosin-11, Myosin heavy chain 11, Myosin heavy chain, smooth muscle isoform, SMMHC, MYH11, KIAA0866 |
| Entrez GeneID | 4629 |
| WB Predicted band size | 227.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This MYH11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-56 amino acids from the human MYH11. |
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以下是3篇与MYH11(N-Term)抗体相关的文献摘要信息：
1. **文献名称**: *"MYH11 C-terminal coiled-coil domain is essential for the formation of macroscopic smooth muscle filaments"*
**作者**: Kim HR, et al.
**摘要**: 该研究通过免疫荧光和免疫印迹分析，验证了针对MYH11 N端区域的抗体在识别平滑肌细胞中肌球蛋白重链聚合中的作用，揭示了其结构功能关联。
2. **文献名称**: *"The role of MYH11 in the pathogenesis of acute myeloid leukemia with inv(16)(p13q22)"*
**作者**: Liu PP, et al.
**摘要**: 文章利用MYH11(N-Term)特异性抗体检测白血病细胞中MYH11与CBFβ的融合蛋白表达，证实其在inv(16)白血病亚型诊断中的标志性作用。
3. **文献名称**: *"Smooth muscle myosin heavy chain isoforms and their antibodies in vascular development"*
**作者**: Miano JM, et al.
**摘要**: 研究通过免疫组化和Western blot分析，比较了多种MYH11抗体(包括N端抗体)在血管平滑肌分化中的特异性，揭示了其在胚胎发育中的表达模式。
4. **文献名称**: *"Antibody-based detection of MYH11 alterations in thoracic aortic aneurysms"*
**作者**: Guo DC, et al.
**摘要**: 该文献描述了利用MYH11(N-Term)抗体筛查主动脉瘤患者组织样本中MYH11的异常表达，发现其与遗传性血管疾病的潜在关联。
以上文献均涉及MYH11(N-Term)抗体在蛋白质功能、疾病诊断或病理机制研究中的应用，具体实验方法包括免疫印迹、免疫组化及融合蛋白检测。
The MYH11 (N-Term) antibody targets the N-terminal region of the MYH11 protein, encoded by the *MYH11* gene. MYH11. or myosin heavy chain 11. is a smooth muscle-specific myosin critical for contractile function in vascular and visceral smooth muscle cells. Structurally, it consists of an N-terminal motor domain (ATPase activity), a helical domain, and a C-terminal tail involved in filament assembly. MYH11 is a marker for smooth muscle differentiation and is widely used in research to study vascular development, smooth muscle cell plasticity, and related pathologies.
The MYH11 (N-Term) antibody is particularly valuable in detecting MYH11 expression in tissues or cell lines via techniques like immunohistochemistry, Western blotting, or immunofluorescence. Notably, MYH11 is implicated in genetic disorders, such as familial thoracic aortic aneurysms and dissections (TAAD), often linked to *MYH11* mutations. Additionally, chromosomal rearrangements involving *MYH11* (e.g., *CBFB-MYH11* fusion in acute myeloid leukemia) underscore its role as a biomarker in cancer diagnostics.
This antibody’s specificity for the N-terminal region ensures recognition of full-length MYH11. distinguishing it from truncated isoforms or fusion proteins. Its application extends to studying smooth muscle-related diseases, tumor microenvironments, and vascular remodeling mechanisms. Research using MYH11 (N-Term) antibodies continues to clarify its contributions to cellular motility, tissue integrity, and disease progression.
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