| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 2T7, OST723, olfactory receptor OR1-44, OR2T7, OR2T7P |
| WB Predicted band size | 34.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR2T7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 264-299 amino acids from the C-terminal region of human OR2T7. |
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以下是关于OR2T7抗体的示例参考文献(注：以下内容为模拟示例，实际文献需通过学术数据库验证)：
1. **《Characterization of a novel polyclonal antibody against human olfactory receptor OR2T7》**
- 作者：Smith A, et al.
- 摘要：本研究开发了一种针对人嗅觉受体OR2T7的多克隆抗体，并通过免疫印迹和免疫组化验证其特异性。结果显示，OR2T7在嗅觉上皮和睾丸组织中特异性表达，提示其潜在生理功能。
2. **《OR2T7 expression in colorectal cancer: A potential biomarker study using immunohistochemistry》**
- 作者：Li X, et al.
- 摘要：通过OR2T7抗体进行免疫组化分析，发现OR2T7在结直肠癌组织中表达显著上调，且与患者预后相关，可能作为肿瘤微环境中的新型生物标志物。
3. **《Olfactory receptor OR2T7 signaling in airway inflammation》**
- 作者：Chen L, et al.
- 摘要：利用OR2T7特异性抗体，研究揭示了OR2T7在气道炎症中的表达及信号通路，表明其可能通过调控NF-κB通路参与炎症反应。
4. **《Cross-reactivity evaluation of commercial OR2T7 antibodies in human and mouse tissues》**
- 作者：Wang Y, et al.
- 摘要：系统评估了市售OR2T7抗体的物种交叉反应性，发现部分抗体存在非特异性结合，强调抗体验证在嗅觉受体研究中的重要性。
建议通过PubMed或Google Scholar以“OR2T7 antibody”或“OR2T7 olfactory receptor”为关键词检索最新文献。
The OR2T7 antibody is a research tool designed to target the olfactory receptor 2T7 (OR2T7), a member of the G protein-coupled receptor (GPCR) superfamily. Olfactory receptors, primarily known for their role in odorant detection, are expressed in olfactory sensory neurons. However, emerging studies suggest ectopic expression of ORs, including OR2T7. in non-olfactory tissues, implicating potential roles in cellular processes like proliferation, differentiation, and disease pathways. OR2T7 remains understudied compared to other ORs, with limited data on its specific ligands or physiological functions.
Antibodies against OR2T7 are typically developed for immunohistochemistry, Western blotting, or flow cytometry to map its expression patterns and investigate its biological relevance. Challenges in creating specific OR2T7 antibodies arise from the high sequence homology among OR family members and the difficulty in producing stable recombinant OR2T7 protein for immunization. Validation often includes knockdown/knockout controls and cross-reactivity screening.
Recent interest in OR2T7 stems from exploratory studies linking olfactory receptors to cancer (e.g., prostate, colorectal) and metabolic disorders. Researchers utilize OR2T7 antibodies to probe its potential as a diagnostic biomarker or therapeutic target. However, commercial availability remains limited, and most applications are confined to experimental models. Further characterization of OR2T7's signaling mechanisms and pathophysiological roles is needed to expand the utility of its corresponding antibodies.
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