| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase LMTK3, Apoptosis-associated tyrosine kinase 3, Lemur tyrosine kinase 3, Lmtk3, Aatyk3 |
| Entrez GeneID | 381983 |
| WB Predicted band size | 150.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Lmtk3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 871-905 amino acids from the Central region of Mouse Lmtk3. |
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以下是关于Mouse Lmtk3抗体的3篇参考文献及其摘要概括：
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1. **文献名称**: *LMTK3 regulates cargo-specific endosomal transport via interaction with CLIP-170*
**作者**: Wang Y, et al.
**摘要**: 研究利用小鼠Lmtk3抗体验证Lmtk3蛋白与微管结合蛋白CLIP-170的相互作用，揭示其在调控特定内体运输通路中的作用，影响细胞极性和膜蛋白定位。
2. **文献名称**: *Lmtk3 knockout mice exhibit hippocampal neuronal defects and memory impairment*
**作者**: Suzuki T, et al.
**摘要**: 通过Lmtk3抗体进行免疫组化分析，发现Lmtk3基因敲除小鼠海马神经元树突发育异常，突触功能受损，导致学习记忆能力下降，提示其在中枢神经系统中的关键作用。
3. **文献名称**: *Antibody-based profiling of Lmtk3 in breast cancer progression*
**作者**: Li H, et al.
**摘要**: 研究利用特异性小鼠Lmtk3抗体检测乳腺癌组织样本，发现Lmtk3高表达与肿瘤侵袭性增强及患者预后不良相关，可能作为潜在治疗靶点。
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注：以上文献为示例性内容，实际文献需通过PubMed或学术数据库检索。建议使用关键词"Lmtk3 antibody"+"mouse"或结合具体研究领域(如癌症、神经科学)进一步筛选。
Mouse Lmtk3 (Lemur tyrosine kinase 3) antibody is a tool designed to detect and study the Lmtk3 protein in murine models. Lmtk3. a member of the lemur kinase family, is a transmembrane serine/threonine kinase implicated in diverse cellular processes, including signal transduction, cytoskeletal regulation, and cell cycle progression. Unlike other lemur kinases, Lmtk3 lacks a conserved kinase domain but retains regulatory functions through interactions with signaling pathways such as Wnt/β-catenin and TGF-β. Its expression is observed in various tissues, with notable roles in neuronal development and cancer biology.
Research highlights Lmtk3's involvement in tumor progression, particularly in breast cancer, where it promotes estrogen receptor-alpha (ERα) stability and endocrine therapy resistance. In neurodegenerative contexts, Lmtk3 regulates axonal transport and synaptic plasticity. The Mouse Lmtk3 antibody, typically generated in rabbits or mice using immunogenic peptide fragments, enables specific detection in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Validated for specificity and affinity, this antibody aids in elucidating Lmtk3's mechanistic contributions to disease pathways and potential therapeutic targeting. Recent studies also explore its phosphorylation-dependent interactions and subcellular localization, underscoring its dual roles in health and disease.
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