| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | KN motif and ankyrin repeat domain-containing protein 2, Ankyrin repeat domain-containing protein 25, Matrix-remodeling-associated protein 3, SRC-1-interacting protein, SIP, SRC-interacting protein, SRC1-interacting protein, KANK2, ANKRD25, KIAA1518, MXRA3, SIP |
| Entrez GeneID | 25959 |
| WB Predicted band size | 91.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KANK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 343-376 amino acids from the Central region of human KANK2. |
+ +
以下是关于KANK2抗体的3篇示例参考文献(注：内容为虚构示例，建议通过PubMed等数据库查询真实文献)：
---
1. **文献名称**: *KANK2 regulates cell adhesion and migration via interaction with β1-integrin*
**作者**: Smith A, et al.
**摘要**: 本研究利用KANK2特异性抗体，通过免疫共沉淀和Western blot技术，揭示了KANK2通过结合β1-整合素调控细胞黏附和迁移的分子机制，提示其在癌症转移中的潜在作用。
---
2. **文献名称**: *KANK2 antibody-based profiling identifies its tumor suppressor role in renal cell carcinoma*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(IHC)结合KANK2抗体，发现KANK2在肾癌细胞中表达显著下调，其低表达与患者不良预后相关，证实KANK2作为抑癌基因的功能。
---
3. **文献名称**: *KANK2 interacts with the cytoskeletal network through ANK repeats: Insights from antibody-mediated inhibition assays*
**作者**: Gupta R, et al.
**摘要**: 研究使用KANK2抗体阻断其功能，证明KANK2的ANK结构域通过与肌动蛋白结合调控细胞骨架重塑，影响神经元轴突导向。
---
建议通过**PubMed**或**Google Scholar**检索关键词“KANK2 antibody”或“KANK2 function”获取真实文献。
The KANK2 antibody targets the KANK2 (KN motif and ankyrin repeat domain-containing protein 2), a member of the KANK family implicated in cytoskeletal organization and cell adhesion. KANK2. encoded by the *KANK2* gene on chromosome 19p13.3. contains conserved N-terminal KN motifs and C-terminal ankyrin repeats, facilitating interactions with proteins like β1-integrin and actin regulators. It plays roles in cell polarity, migration, and mechanotransduction by bridging the cytoskeleton and membrane receptors. Dysregulation of KANK2 is linked to cancers, neurological disorders, and kidney diseases, with studies suggesting its tumor-suppressive role in certain contexts.
KANK2 antibodies are essential tools for detecting protein expression, localization, and interactions in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Researchers use these antibodies to explore KANK2's involvement in disease pathways, such as epithelial-mesenchymal transition or renal dysfunction. Commercial KANK2 antibodies vary in specificity, often validated against recombinant proteins or tissue lysates. Epitope mapping is critical, as some antibodies target N-terminal regions (e.g., residues 1-300) or C-terminal domains, influencing experimental outcomes. Proper validation with knockout controls ensures reliability, aiding studies on KANK2's molecular mechanisms and therapeutic potential.
×
