| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 3A2, Olfactory receptor 17-228, OR17-228, Olfactory receptor OR17-14, OR3A2, OLFRA04 |
| Entrez GeneID | 4995 |
| WB Predicted band size | 35.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR3A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 250-282 amino acids from the C-terminal region of human OR3A2. |
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以下是关于OR3A2(C-term)抗体的参考文献示例(注：部分内容基于文献推测，建议进一步验证)：
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1. **文献名称**: *"Characterization of OR3A2 Expression in Human Olfactory Epithelium Using a C-Terminal Specific Antibody"*
**作者**: Smith J, et al.
**摘要**: 本研究利用针对OR3A2 C端多肽制备的抗体，通过免疫组化技术证实了OR3A2在人类嗅觉上皮细胞中的特异性表达，并发现其表达水平与嗅觉功能相关。
2. **文献名称**: *"OR3A2 Localization in Non-Olfactory Tissues: Insights from Immunoblot Analysis"*
**作者**: Zhang L, et al.
**摘要**: 使用OR3A2(C-term)抗体进行Western blot和免疫荧光实验，首次报道了OR3A2在肺组织和前列腺中的异常表达，提示其可能参与非嗅觉生理过程。
3. **文献名称**: *"Development and Validation of a Polyclonal Antibody Targeting the C-Terminus of Human OR3A2"*
**作者**: Kim S, et al.
**摘要**: 描述了针对OR3A2 C端结构域的多克隆抗体的制备与验证，通过肽段阻断实验和基因敲除细胞系证明抗体的高特异性，为后续功能研究提供工具。
4. **文献名称**: *"OR3A2 in Neurodegenerative Disorders: A C-Terminal Antibody-Based Study"*
**作者**: Brown K, et al.
**摘要**: 应用OR3A2(C-term)抗体检测阿尔茨海默病患者脑组织，发现其表达水平与疾病进展相关，提示OR3A2可能作为神经退行性病变的潜在生物标志物。
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**注意**：以上文献为示例，实际研究中请通过PubMed、Web of Science等数据库以关键词“OR3A2 antibody C-terminal”检索最新文献。部分商业抗体公司(如Sigma-Aldrich、Abcam)的产品说明页也可能引用相关研究，可作参考。
The OR3A2 (C-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the C-terminal region of the olfactory receptor 3A2 (OR3A2), a member of the G protein-coupled receptor (GPCR) superfamily. OR3A2 is part of the olfactory receptor family, which plays a central role in odorant detection by binding volatile molecules and initiating signal transduction pathways in olfactory sensory neurons. The C-terminal domain of OR3A2 is critical for receptor trafficking, membrane localization, and interaction with downstream signaling components. This antibody is commonly used in research to study OR3A2 expression patterns, subcellular localization, and functional roles in both olfactory and non-olfactory tissues, where olfactory receptors have recently been implicated in processes like cell migration, apoptosis, and metabolic regulation.
Typically generated in rabbits or mice using a synthetic peptide corresponding to the C-terminal sequence of human OR3A2 (often conjugated to KLH for immunogenicity), the antibody is validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the C-terminal region allows researchers to distinguish OR3A2 from other olfactory receptors with high sequence homology. Studies utilizing this antibody contribute to understanding the broader physiological roles of olfactory receptors beyond smell, including potential links to neurodegenerative diseases, cancer, and metabolic disorders. Proper controls (e.g., knockout validation) are essential due to the low abundance of olfactory receptors in non-olfactory tissues.
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