| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Son of sevenless homolog 1, SOS-1, SOS1 |
| Entrez GeneID | 6654 |
| WB Predicted band size | 152.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SOS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 934-962 amino acids from the Central region of human SOS1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SOS1抗体的3篇代表性文献示例(注：以下为模拟内容，实际文献需通过学术数据库查询)：
1. **文献名称**：*Targeting SOS1 overcomes RTK-mediated resistance to anti-EGFR therapies in colorectal cancer*
**作者**：Smith J, et al.
**摘要**：该研究利用SOS1特异性抗体(如单克隆抗体)阻断EGFR-RAS信号通路，发现抑制SOS1可逆转结直肠癌细胞对EGFR抑制剂的耐药性，揭示了SOS1作为治疗靶点的潜力。
2. **文献名称**：*SOS1 mutations disrupt RAS/MAPK signaling in Noonan syndrome: Diagnostic implications of antibody-based assays*
**作者**：Garcia-Ruiz C, et al.
**摘要**：通过SOS1抗体进行免疫印迹和免疫组化分析，研究努南综合征患者中SOS1突变对蛋白表达及定位的影响，证实抗体检测可用于临床突变筛查及功能研究。
3. **文献名称**：*Development of a high-affinity SOS1 monoclonal antibody for functional interrogation of RAS activation*
**作者**：Li X, et al.
**摘要**：报道了一种新型SOS1单克隆抗体的开发，该抗体可特异性识别SOS1的GEF结构域，阻断其与RAS的相互作用，显著抑制癌细胞增殖，为靶向RAS通路的药物研发提供工具。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“SOS1 antibody”“SOS1 therapeutic targeting”或“SOS1 RAS signaling”获取最新研究。
The SOS1 (Son of Sevenless homolog 1) protein is a guanine nucleotide exchange factor (GEF) that activates RAS signaling by promoting the conversion of RAS-GDP to its active GTP-bound form. It plays a critical role in regulating cell proliferation, differentiation, and survival through the RAS-MAPK pathway. Dysregulation of SOS1. often due to mutations or overexpression, has been implicated in various cancers, including lung, colon, and pancreatic malignancies, as well as developmental disorders like Noonan syndrome.
SOS1 antibodies are tools used in research to study its expression, localization, and interaction with signaling components. In clinical contexts, anti-SOS1 antibodies may serve as biomarkers for autoimmune diseases. For example, autoantibodies against SOS1 have been detected in some patients with Sjögren’s syndrome or systemic lupus erythematosus (SLE), though their pathogenic role remains unclear.
Therapeutically, targeting SOS1 has gained interest as a strategy to inhibit oncogenic RAS signaling, particularly in tumors resistant to direct RAS inhibitors. Monoclonal antibodies or small-molecule inhibitors disrupting SOS1-RAS interactions are under investigation. However, challenges include ensuring specificity and minimizing off-target effects due to SOS1’s complex regulatory networks. Ongoing studies aim to elucidate SOS1’s role in disease and optimize antibody-based diagnostics or therapies.
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