| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 7B4; CD144 |
| Entrez GeneID | 1003 |
| clone | 3D5C7 |
| WB Predicted band size | 87.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human CDH5 (AA: 29-223 ) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于ADAMTS6 (N-Term)抗体的参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询确认)：
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1. **标题**: *"ADAMTS6 Expression and Function in Cardiovascular Development"*
**作者**: Smith J, et al.
**摘要**: 本研究利用针对ADAMTS6 N端结构域的多克隆抗体，通过免疫组化和Western blot分析，揭示了该蛋白在小鼠胚胎心脏瓣膜发育中的动态表达模式。研究证实ADAMTS6通过调控细胞外基质重塑影响心脏形态发生。
2. **标题**: *"Characterization of a Novel ADAMTS6-Specific Antibody for Proteolytic Activity Studies"*
**作者**: Lee H, et al.
**摘要**: 文章报道了一种新型ADAMTS6 (N-Term)单克隆抗体的开发与验证。该抗体可特异性识别ADAMTS6的N端结构域，成功应用于免疫共沉淀实验，并证明其能抑制ADAMTS6对纤连蛋白的切割活性。
3. **标题**: *"ADAMTS6 in Tumor Stroma: Immunohistochemical Analysis Using Domain-Specific Antibodies"*
**作者**: Garcia R, et al.
**摘要**: 通过ADAMTS6 N端抗体对多种癌症组织进行染色，研究发现ADAMTS6在肿瘤间质成纤维细胞中高表达，且与患者生存率负相关，提示其可能作为癌症预后的生物标志物。
4. **标题**: *"Functional Redundancy of ADAMTS Proteases: Insights from N-Terminal Epitope Tagging"*
**作者**: Wang Y, et al.
**摘要**: 研究利用N端抗体对比ADAMTS家族多个成员的表达定位，发现ADAMTS6在软骨细胞分化中与ADAMTS5存在功能互补，抗体阻断实验进一步验证了其在胶原代谢中的独特作用。
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建议通过PubMed或Google Scholar以关键词“ADAMTS6 antibody N-terminal”或“ADAMTS6 epitope mapping”检索最新文献以获取真实数据。
**Background of ADAMTS6 (N-Term) Antibody**
ADAMTS6 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 6) is a member of the ADAMTS family of secreted zinc-dependent proteases, known for their roles in extracellular matrix (ECM) remodeling, cell adhesion, and proteolytic processing of bioactive molecules. The N-terminal region of ADAMTS6 contains critical domains, including the propeptide and metalloproteinase domains, which are essential for its zymogen activation, substrate recognition, and enzymatic activity.
The ADAMTS6 (N-Term) antibody is specifically designed to target epitopes within the N-terminal region of the protein. This antibody is commonly used in research to detect full-length ADAMTS6 or its processed forms in various experimental applications, such as Western blotting, immunohistochemistry, and immunoprecipitation. By focusing on the N-terminal region, the antibody helps distinguish ADAMTS6 from other ADAMTS family members and provides insights into its expression, post-translational processing, and functional regulation.
ADAMTS6 has been implicated in developmental processes, tissue homeostasis, and disease pathologies, including cardiovascular disorders and fibrosis. Studies using the N-Term antibody have contributed to understanding its role in ECM dynamics, growth factor modulation, and cellular signaling pathways. Validated for specificity and sensitivity, this antibody serves as a key tool for exploring ADAMTS6's biological and clinical relevance.
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