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Rabbit Polyclonal (Mouse)Trex2 Antibody

  • 中文名: (Mouse) Trex2抗体
  • 别    名: Three prime repair exonuclease 2, 3'-5' exonuclease TREX2, Trex2
货号: IPDX33149
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesThree prime repair exonuclease 2, 3'-5' exonuclease TREX2, Trex2
Entrez GeneID24102
WB Predicted band size26.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis Mouse Trex2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 223-276 amino acids from the C-terminal region of Mouse Trex2.

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参考文献

以下是关于小鼠Trex2抗体的3篇参考文献示例(注:文献为模拟,实际引用需核实):

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1. **文献名称**: *"Characterization of Trex2 nuclease activity in mouse embryonic stem cells"*

**作者**: Smith A, et al.

**摘要**: 本研究利用特异性抗小鼠Trex2的多克隆抗体,通过免疫沉淀和Western blot技术,揭示了Trex2在小鼠胚胎干细胞DNA损伤修复中的核酸酶活性及其对基因组稳定性的影响。

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2. **文献名称**: *"Development of a monoclonal antibody against mouse Trex2 and its application in neurodevelopmental studies"*

**作者**: Johnson R, et al.

**摘要**: 作者报道了一种高特异性抗小鼠Trex2的单克隆抗体的开发,并通过免疫荧光和流式细胞术证明Trex2在小鼠大脑皮层神经元中的动态表达,提示其在神经发育中的潜在作用。

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3. **文献名称**: *"Trex2 deficiency in mice leads to impaired spermatogenesis: Insights from antibody-based localization"*

**作者**: Lee H, et al.

**摘要**: 通过抗Trex2抗体的组织免疫染色,研究发现Trex2敲除小鼠的精子发生过程存在严重缺陷,表明Trex2在生殖细胞DNA重组和凋亡调控中起关键作用。

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如需具体文献,建议通过PubMed或Google Scholar以“Trex2 antibody mouse”、“Trex2 function”等关键词检索近年论文。

背景信息

The mouse Trex2 (Three Prime Repair Exonuclease 2) antibody is a tool used to detect and study the Trex2 protein in murine models. Trex2. a 3'→5' exonuclease, plays critical roles in DNA repair, genome stability, and immune diversification. It is involved in processing DNA damage, trimming mismatched DNA ends during repair, and contributing to somatic hypermutation in antibody diversification. The antibody is typically generated by immunizing hosts (e.g., rabbits or mice) with a synthetic peptide or recombinant protein corresponding to a specific epitope of mouse Trex2. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze Trex2 expression, localization, and function in tissues or cells. Studies leveraging this antibody have explored Trex2's role in cancer, neurodegeneration, and immune disorders. Validation often includes testing in Trex2-knockout models to confirm specificity. Research highlights its interaction with proteins like PCNA (Proliferating Cell Nuclear Antigen) and its impact on genomic integrity, making it a focus in DNA repair mechanisms and therapeutic targeting. The antibody's utility extends to both basic research and preclinical studies in genetically engineered mouse models.

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