Rabbit Polyclonal (Mouse)Trex2 Antibody

The mouse Trex2 (Three Prime Repair Exonuclease 2) antibody is a tool used to detect and study the Trex2 protein in murine models. Trex2. a 3'→5' exonuclease, plays critical roles in DNA repair, genome stability, and immune diversification. It is involved in processing DNA damage, trimming mismatched DNA ends during repair, and contributing to somatic hypermutation in antibody diversification. The antibody is typically generated by immunizing hosts (e.g., rabbits or mice) with a synthetic peptide or recombinant protein corresponding to a specific epitope of mouse Trex2. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze Trex2 expression, localization, and function in tissues or cells. Studies leveraging this antibody have explored Trex2's role in cancer, neurodegeneration, and immune disorders. Validation often includes testing in Trex2-knockout models to confirm specificity. Research highlights its interaction with proteins like PCNA (Proliferating Cell Nuclear Antigen) and its impact on genomic integrity, making it a focus in DNA repair mechanisms and therapeutic targeting. The antibody's utility extends to both basic research and preclinical studies in genetically engineered mouse models.