Rabbit Polyclonal (DANRE)shq1 Antibody

The DANRE/shq1 antibody is a research tool specifically designed to detect and study the SHQ1 protein in the zebrafish (*Danio rerio*) model system. SHQ1 is a conserved eukaryotic protein critical for the biogenesis of H/ACA small nucleolar ribonucleoproteins (snoRNPs), which guide chemical modifications of ribosomal RNA (rRNA) and small nuclear RNA (snRNA). These modifications are essential for ribosome assembly, RNA splicing, and overall cellular homeostasis. In zebrafish, SHQ1 is implicated in early developmental processes due to its role in rRNA processing and telomerase RNA maturation. Mutations or dysregulation of SHQ1 have been linked to human genetic disorders, including congenital dyskeratosis and certain cancers, making zebrafish a valuable model for studying its function in vivo. The DANRE/shq1 antibody, often produced in rabbits or mice using immunogenic peptides derived from zebrafish SHQ1. enables techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein expression, localization, and dynamics during embryogenesis or disease states. Its application has advanced understanding of SHQ1's contributions to tissue development, stem cell maintenance, and disease mechanisms, particularly in contexts where rRNA biogenesis is disrupted. This antibody is a key resource in developmental biology and translational research exploring RNA-processing-related pathologies.