| WB | 1/2000 | zebrafish |
| IF | 咨询技术 | zebrafish |
| IHC | 咨询技术 | zebrafish |
| ICC | 技术咨询 | zebrafish |
| FCM | 咨询技术 | zebrafish |
| Elisa | 咨询技术 | zebrafish |
| Aliases | Alpha-2A adrenergic receptor, Alpha-2A adrenoreceptor, Alpha-2A adrenoceptor, Alpha-2AAR, adra2a |
| WB Predicted band size | 44.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | zebrafish |
| Immunogen | This DANRE adra2a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 223-256 amino acids from the Central region of DANRE adra2a. |
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以下是关于斑马鱼(Danio rerio)ADRA2A抗体的3篇参考文献的简要概括：
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1. **标题**：*Characterization of α2-adrenergic receptor subtypes in zebrafish: Expression and function in cardiac development*
**作者**：Ruuskanen, J.O., et al.
**摘要**：本研究利用针对ADRA2A的抗体，通过免疫组织化学和Western blot技术，揭示了斑马鱼胚胎心脏发育过程中该受体的时空表达模式，并证实其参与调节心率及心肌细胞分化。
2. **标题**：*ADRA2A-mediated signaling in zebrafish larval locomotor behavior*
**作者**：Steenbergen, P.J., et al.
**摘要**：文章通过ADRA2A特异性抗体检测中枢神经系统中的受体分布，结合药理学实验，证明ADRA2A在斑马鱼幼体运动控制中起关键作用，并影响多巴胺能神经通路的调控。
3. **标题**：*Antibody validation and functional analysis of α2A-adrenergic receptor in zebrafish models of anxiety*
**作者**：Zhang, Y., et al.
**摘要**：研究验证了一种新型ADRA2A抗体的特异性，并应用于斑马鱼焦虑模型中，显示该受体在前脑区域的表达上调与应激行为相关，为神经精神疾病研究提供工具。
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注：上述文献为示例性质，实际引用时需核实真实存在的论文及细节。建议通过PubMed或Web of Science以关键词“zebrafish ADRA2A antibody”进一步检索最新文献。
The adrenergic receptor alpha 2A (ADRA2A) is a G protein-coupled receptor that mediates physiological responses to norepinephrine and epinephrine, playing key roles in regulating neurotransmitter release, blood pressure, and sympathetic nervous system activity. In zebrafish (*Danio rerio*), ADRA2A is evolutionarily conserved and widely expressed in the central nervous system, cardiovascular tissues, and other organs, making it a critical target for studying neuroendocrine signaling, stress responses, and cardiovascular function.
The DANRE ADRA2A antibody is a research tool specifically developed to detect and localize the ADRA2A protein in zebrafish models. It is commonly used in immunohistochemistry, Western blotting, and immunofluorescence to investigate receptor distribution, expression levels, and functional roles during development or disease states. Zebrafish, with their genetic tractability and transparent embryos, offer a powerful platform for *in vivo* studies of ADRA2A's involvement in behaviors, autonomic regulation, and pharmacological responses.
This antibody’s validation typically includes specificity tests using knockout models or blocking peptides, ensuring reliability in distinguishing ADRA2A from related adrenergic receptors. Its applications span developmental biology, neuropharmacology, and disease modeling, particularly in studies exploring hypertension, anxiety-like behaviors, or drug mechanisms targeting adrenergic pathways. By enabling precise protein detection, the DANRE ADRA2A antibody supports advancing insights into conserved adrenergic signaling mechanisms across vertebrates.
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