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Rabbit Polyclonal (Mouse)Smarcc1 Antibody

  • 中文名: (Mouse) Smarcc1抗体
  • 别    名: SWI/SNF complex subunit SMARCC1, BRG1-associated factor 155, SWI/SNF complex 155 kDa subunit, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1, SWI3-related protein, BAF155, Smarcc1, Baf155, Srg3
货号: IPDX32989
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 1/25 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSWI/SNF complex subunit SMARCC1, BRG1-associated factor 155, SWI/SNF complex 155 kDa subunit, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1, SWI3-related protein, BAF155, Smarcc1, Baf155, Srg3
Entrez GeneID20588
WB Predicted band size122.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis Mouse Smarcc1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 783-817 amino acids from the C-terminal region of Mouse Smarcc1.

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参考文献

以下是关于小鼠Smarcc1抗体的3篇参考文献示例(注:文献为虚构示例,实际引用需核实):

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1. **文献名称**: *Smarcc1 regulates pluripotency exit in mouse embryonic stem cells via chromatin remodeling*

**作者**: Ho, L., et al.

**摘要**: 本研究利用Smarcc1特异性抗体(Western blot和ChIP-seq)证明,Smarcc1通过调控SWI/SNF复合体结合到多能性基因启动子区,维持小鼠胚胎干细胞的自我更新。敲除Smarcc1导致分化相关基因异常激活。

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2. **文献名称**: *Smarcc1 loss drives tumorigenesis in a mouse model of pancreatic cancer*

**作者**: Medina, P.P., et al.

**摘要**: 通过免疫组化(Smarcc1抗体)和条件性基因敲除小鼠模型,研究发现Smarcc1缺失导致染色质可及性改变,促进胰腺癌中致癌信号通路(如Wnt/β-catenin)的异常激活。

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3. **文献名称**: *Smarcc1 coordinates neural progenitor differentiation via epigenetic regulation*

**作者**: Staahl, B.T., et al.

**摘要**: 该研究利用Smarcc1抗体进行免疫共沉淀和染色质分析,揭示Smarcc1在小鼠大脑发育中通过招募组蛋白修饰酶(如HDACs),调控神经前体细胞的分化时序。

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**注**:以上文献为示例,实际研究中请通过PubMed或Google Scholar检索具体文献(关键词:Smarcc1/BAF155 antibody, mouse)。若需验证抗体特异性,建议参考抗体供应商提供的引用文献(如CST、Abcam等品牌)。

背景信息

The Smarcc1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1) antibody is a tool used to detect the Smarcc1 protein, a critical component of the mammalian SWI/SNF (BAF) chromatin remodeling complex. Smarcc1. also known as BAF155. plays essential roles in regulating gene expression by altering chromatin structure through ATP-dependent nucleosome repositioning. This protein is involved in diverse cellular processes, including differentiation, proliferation, and DNA repair. The antibody is typically developed in host species like rabbit or mouse using immunogenic peptides or recombinant protein fragments corresponding to specific epitopes of the murine Smarcc1. It is widely utilized in techniques such as Western blotting, immunohistochemistry, immunoprecipitation, and chromatin immunoprecipitation (ChIP) to study Smarcc1's expression, localization, and interactions in various tissues and disease models. Validation often includes knockout controls or siRNA knockdown to confirm specificity. Researchers employ this antibody to investigate Smarcc1's role in development, cancer (where SWI/SNF subunits are frequently mutated), and epigenetic regulation. Commercial versions may vary in clonality (monoclonal/polyclonal), conjugates, and recommended applications, requiring optimization for experimental conditions.

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