| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Abelson tyrosine-protein kinase 2, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, ABL2, ABLL, ARG |
| Entrez GeneID | 27 |
| WB Predicted band size | 128.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ABL2 antibody is generated from a mouse immunized with a recombinant protein. |
+ +
以下是关于ABL2抗体的3篇参考文献示例(内容基于模拟生成，建议通过学术数据库核实具体文献)：
1. **文献名称**：**"A monoclonal antibody targeting ABL2 inhibits tumor metastasis in preclinical models"**
**作者**：Chen L, et al.
**摘要**：该研究开发了一种针对ABL2激酶结构域的单克隆抗体，通过体外和体内实验证明其能够抑制ABL2的活性，减少癌细胞迁移和侵袭，为靶向ABL2的癌症治疗提供了潜在工具。
2. **文献名称**：**"Characterization of ABL2-specific antibodies for functional proteomics analysis"**
**作者**：Park S, et al.
**摘要**：作者比较了多种市售ABL2抗体的特异性，验证了其在Western blot、免疫沉淀和免疫荧光中的应用，发现某些抗体存在与ABL1的交叉反应，强调了选择高特异性抗体对研究ABL2功能的重要性。
3. **文献名称**：**"ABL2 phosphorylation dynamics revealed by phospho-specific antibodies in neuronal development"**
**作者**：Rodriguez A, et al.
**摘要**：研究团队开发了针对ABL2特定磷酸化位点的抗体，利用其揭示了ABL2在神经元分化中的动态激活机制，表明其在神经发育和疾病中的潜在调控作用。
如需具体文献，建议通过PubMed或Google Scholar以关键词“ABL2 antibody”、“anti-ABL2 application”检索近期研究。
The ABL2 antibody targets the ABL2 tyrosine kinase, encoded by the *ABL2* gene (also known as *ARG*), which belongs to the Abelson (ABL) family of non-receptor tyrosine kinases. ABL2 shares structural and functional similarities with ABL1. including SH3. SH2. and kinase domains, but differs in its N-terminal region and cellular roles. While ABL1 is well-studied in hematologic malignancies (e.g., BCR-ABL1 in chronic myeloid leukemia), ABL2 is primarily associated with cytoskeletal regulation, cell migration, and adhesion. It interacts with proteins like CRK, vinculin, and paxillin to modulate actin dynamics, influencing processes such as neuronal development, immune cell trafficking, and cancer metastasis.
ABL2 antibodies are critical tools for studying its expression, activation, and signaling in physiological and pathological contexts. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ABL2 levels, phosphorylation status (e.g., Tyr-439/476), or localization in tissues or cell lines. Dysregulation of ABL2 has been implicated in solid tumors (e.g., breast, lung cancers) and neurodegenerative disorders, where aberrant kinase activity promotes invasiveness or synaptic dysfunction. Both monoclonal and polyclonal ABL2 antibodies are available, often validated for specificity via knockout controls. Research using these antibodies aims to uncover ABL2's role in disease mechanisms and its potential as a therapeutic target, particularly in cancers resistant to ABL1 inhibitors.
×
