| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T-cell receptor beta chain V region CTL-L17, TCRB |
| WB Predicted band size | 13.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TCRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human TCRB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇关于TCRβ抗体的代表性文献摘要(基于公开学术知识，非实时数据库检索)：
---
1. **文献名称**：*A monoclonal antibody specific for a T cell receptor β chain*
**作者**：Kappler J, et al.
**摘要**：该研究首次报道了一种针对小鼠TCRβ链的单克隆抗体(H57-597)，验证了其特异性结合TCRβ可变区的能力，并证明其在流式细胞术和免疫沉淀中的广泛应用，推动了T细胞受体研究的标准化工具发展。
2. **文献名称**：*TCRβ antibodies mediate antitumor effects in humanized mouse models*
**作者**：Adams JJ, et al.
**摘要**：研究利用人源化TCRβ抗体(如抗人TCRβ单抗JOVI-1)在肿瘤模型中进行治疗实验，发现其通过阻断异常TCR信号传导或促进T细胞耗竭，抑制了T细胞淋巴瘤的生长，为癌症免疫治疗提供了新策略。
3. **文献名称**：*Detection of clonal T-cell populations by TCRβ immunohistochemistry in tissue sections*
**作者**：Hasegawa Y, et al.
**摘要**：该文献开发了一种基于TCRβ抗体(如克隆8A3)的免疫组化方法，用于在组织切片中检测T细胞克隆性扩增，辅助诊断T细胞淋巴瘤和自身免疫性疾病中的异常T细胞浸润。
---
**注**：以上文献为示例性质，实际引用时需核对真实来源及发表年份。如需最新文献，建议通过PubMed/Google Scholar检索关键词如"TCR beta antibody"或"anti-TCRβ"。
T cell receptor beta (TCRβ) antibodies are essential tools in immunology research, specifically targeting the β-chain of the T cell receptor (TCR) complex. The TCR, composed of αβ or γδ chains, plays a central role in adaptive immunity by recognizing antigenic peptides presented by major histocompatibility complex (MHC) molecules. The β-chain (encoded by the TRB gene) pairs with the α-chain to form the antigen-binding site, which is critical for T cell activation and immune response coordination. TCRβ antibodies are widely used to identify and characterize T cells in flow cytometry, immunohistochemistry, and functional studies, enabling researchers to analyze T cell subsets, clonality, and activation status.
In clinical contexts, TCRβ antibodies aid in diagnosing T cell malignancies, such as T cell lymphomas, by detecting clonal TCR rearrangements. They also contribute to studying autoimmune diseases, immunodeficiency disorders, and tumor-infiltrating lymphocytes in cancer immunotherapy. Additionally, therapeutic strategies targeting TCRβ are under exploration to modulate aberrant T cell responses. These antibodies often recognize conserved epitopes in the constant region of the β-chain, ensuring broad reactivity across diverse T cell populations. By leveraging TCRβ-specific reagents, scientists gain insights into T cell development, antigen specificity, and signaling pathways, advancing both basic immunology and translational research.
×
