| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B |
| Entrez GeneID | 3170 |
| WB Predicted band size | 48.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FOXA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 355-389 amino acids from the C-terminal region of human FOXA2. |
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1. **"FOXA2 is required for enhancer priming during pancreatic differentiation"** by D'Amour et al.
*摘要*：研究利用FOXA2抗体揭示其在胚胎干细胞向胰腺β细胞分化中的关键作用，证明FOXA2通过调控染色质可及性驱动胰腺发育。
2. **"FOXA2 suppresses epithelial-mesenchymal transition and metastasis in gastric cancer"** by Gao et al.
*摘要*：通过FOXA2抗体检测发现，FOXA2在胃癌中低表达且与EMT进程负相关，过表达FOXA2可抑制肿瘤转移。
3. **"FOXA2 regulates alveolarization by modulating Wnt signaling in the developing lung"** by Wan et al.
*摘要*：利用FOXA2抗体染色技术，揭示其在肺发育中通过调控Wnt通路影响肺泡形成，缺失导致呼吸功能障碍。
4. **"Loss of FOXA2 induces lipid accumulation and fibrosis during liver injury"** by Lee et al.
*摘要*：研究使用FOXA2抗体分析肝纤维化模型，发现FOXA2下调导致脂代谢紊乱及纤维化，提示其肝脏保护功能。
The FOXA2 antibody is a crucial tool in biomedical research for detecting Forkhead Box A2 (FOXA2), a transcription factor belonging to the forkhead box (FOX) family. FOXA2. also known as Hepatocyte Nuclear Factor 3-beta (HNF3β), plays a pivotal role in embryonic development, particularly in endoderm-derived organs such as the liver, pancreas, lungs, and prostate. It regulates gene expression by binding to DNA and modulating chromatin structure, facilitating the differentiation of progenitor cells into specialized cell types. In adults, FOXA2 is essential for maintaining metabolic homeostasis, including glucose and lipid metabolism, and is involved in the function of pancreatic β-cells and hepatocytes.
FOXA2 antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP) to study protein expression, localization, and DNA interactions. These antibodies are critical in research on developmental biology, cancer (where FOXA2 may act as a tumor suppressor or promoter depending on context), and metabolic disorders. Commercially available FOXA2 antibodies are often raised in hosts like rabbits or mice, with clones validated for specificity using knockout cell lines or tissues. Researchers rely on these antibodies to explore FOXA2's role in organogenesis, disease mechanisms, and potential therapeutic targets.
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