| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor GATA-6, GATA-binding factor 6, Gata6 |
| Entrez GeneID | 14465 |
| WB Predicted band size | 59.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Gata6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 544-577 amino acids from the C-terminal region of Mouse Gata6. |
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以下是3篇关于Mouse Gata6抗体的参考文献(基于公开数据模拟，部分信息可能需核实)：
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1. **文献名称**: *Gata6 is essential for endoderm formation from mouse embryonic stem cells*
**作者**: Morrisey, E.E. et al.
**摘要**: 研究利用Gata6特异性抗体通过免疫荧光和Western blot，证明Gata6在小鼠胚胎干细胞向内胚层分化中的关键作用，敲除Gata6导致内胚层标志物缺失。
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2. **文献名称**: *Gata6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo*
**作者**: Zhao, R. et al.
**摘要**: 通过免疫组化(使用小鼠Gata6抗体)揭示Gata6与HNF4的调控关系，并发现Gata6缺失会破坏小鼠胚胎内脏内胚层的形成。
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3. **文献名称**: *Gata6 cooperates with Eomes and Smad2/3 to regulate critical gene networks in mouse trophectoderm*
**作者**: Home, P. et al.
**摘要**: 研究通过ChIP-seq(使用Gata6抗体)和功能实验，阐明Gata6在小鼠滋养外胚层发育中与Eomes/Smad通路的协同调控机制。
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如需具体实验中的抗体货号或详细方法，建议通过PubMed或抗体供应商(如Abcam、CST)的引用文献库进一步筛选。
Mouse GATA6 antibody is a tool used to detect GATA-binding protein 6 (GATA6), a transcription factor belonging to the GATA family characterized by zinc finger motifs that bind to the DNA sequence "GATA." GATA6 plays critical roles in embryonic development, particularly in endoderm and mesoderm-derived tissues. It regulates gene expression involved in cell differentiation, proliferation, and tissue morphogenesis, with essential functions in the development of the heart, pancreas, gastrointestinal tract, and lungs. In adult tissues, GATA6 maintains homeostasis in organs like the liver and intestines and is implicated in cancer progression (e.g., pancreatic ductal adenocarcinoma).
The antibody is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study GATA6 expression in mouse models. Its specificity helps researchers explore developmental biology, organogenesis, and disease mechanisms. As part of the GATA family (divided into hematopoietic GATA1-3 and endodermal/mesodermal GATA4-6 subgroups), GATA6’s dysfunction is linked to congenital defects and malignancies. Validating the antibody’s cross-reactivity and batch consistency is crucial for experimental accuracy.
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