Rabbit Polyclonal IARS2(N-term) Antibody

The IARS2 (N-term) antibody is designed to target the N-terminal region of isoleucyl-tRNA synthetase 2 (IARS2), a mitochondrial enzyme critical for protein translation. IARS2 belongs to the class I aminoacyl-tRNA synthetase family, which catalyzes the attachment of isoleucine to its cognate tRNA during mitochondrial protein synthesis. This enzyme plays a vital role in maintaining mitochondrial function and cellular energy production. Mutations in the IARS2 gene are associated with mitochondrial disorders, such as Leigh syndrome, growth retardation, and sensorineural hearing loss. The antibody’s specificity for the N-terminal region allows researchers to detect full-length IARS2 or study structural/functional domains in various applications, including Western blotting, immunofluorescence, and immunohistochemistry. Its development aids in investigating IARS2 expression patterns, mitochondrial dysfunction mechanisms, and disease correlations. Studies using this antibody have contributed to understanding IARS2’s role in oxidative phosphorylation, tissue-specific metabolic regulation, and its potential as a biomarker for mitochondrial diseases. Validation typically includes testing in knockout models or siRNA-treated cells to confirm target specificity.