| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase transmembrane receptor ROR2, mROR2, Neurotrophic tyrosine kinase, receptor-related 2, Ror2 |
| WB Predicted band size | 105.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Ror2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 756-790 amino acids from the C-terminal region of human Mouse Ror2. |
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以下是3条关于Mouse Ror2抗体的参考文献示例(内容为虚构，仅供参考格式)：
1. **文献名称**: "Ror2 receptor tyrosine kinase regulates skeletal development through Wnt signaling"
**作者**: Oishi I, et al.
**摘要**: 本研究利用特异性小鼠Ror2抗体，通过免疫组化和Western blot分析，揭示了Ror2在小鼠胚胎肢体发育中通过调控Wnt5a信号通路促进软骨细胞分化的机制。
2. **文献名称**: "Role of Ror2 in neural crest cell migration during craniofacial morphogenesis"
**作者**: Schwabe GC, et al.
**摘要**: 通过Ror2抗体标记技术，作者发现Ror2蛋白在小鼠神经嵴细胞中高表达，并证明其缺失导致细胞迁移异常，进而引发颅面发育缺陷。
3. **文献名称**: "Ror2 antibody-based inhibition of non-canonical Wnt signaling suppresses tumor growth"
**作者**: Green JL, et al.
**摘要**: 该研究开发了高亲和力小鼠Ror2单克隆抗体，体外实验显示其可阻断Wnt5a-Ror2相互作用，并在小鼠移植瘤模型中显著抑制肿瘤侵袭和转移。
(注：以上文献及作者为示例，实际引用需查询真实数据库如PubMed。)
The mouse Ror2 antibody is a crucial tool for studying the receptor tyrosine kinase ROR2. which plays a pivotal role in developmental processes and disease pathways. ROR2. a member of the ROR family of receptors, is involved in non-canonical Wnt signaling, particularly through interactions with Wnt5a. It regulates embryonic development, including skeletal formation, neuronal patterning, and cell migration. Dysregulation of ROR2 is linked to genetic disorders such as Robinow syndrome and brachydactyly type B1. as well as cancers (e.g., osteosarcoma, melanoma), where it often promotes metastasis.
Mouse Ror2 antibodies are designed to detect endogenous ROR2 in murine models, enabling research into its expression, localization, and function. These antibodies are typically validated for applications like Western blotting, immunohistochemistry, and flow cytometry. Specific epitopes, such as extracellular or intracellular domains, are targeted to study receptor-ligand interactions or signaling mechanisms. Validation often includes knockout controls to ensure specificity.
By facilitating the study of ROR2 in development and disease, these antibodies contribute to understanding molecular pathways, evaluating therapeutic targets, and modeling human disorders in mice. Their utility spans basic research, drug discovery, and translational studies.
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