| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, Nuclear LIM interactor-interacting factor 3, NLI-IF, NLI-interacting factor 3, Small C-terminal domain phosphatase 1, SCP1, Small CTD phosphatase 1, CTDSP1, NIF3, NLIIF, SCP1 |
| Entrez GeneID | 58190 |
| WB Predicted band size | 29.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CTDSP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 16-50 amino acids from the N-terminal region of human CTDSP1. |
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以下是关于CTDSP1 (N-term)抗体的模拟参考文献示例。请注意，这些文献为假设性示例，实际文献需通过学术数据库进一步检索：
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1. **文献名称**：*CTDSP1 regulates TGF-β signaling through dephosphorylation of Smad2/3*
**作者**：Zhang L, et al.
**摘要**：本研究利用CTDSP1 (N-term)抗体进行免疫沉淀和Western blot分析，发现CTDSP1通过介导Smad2/3的C端磷酸化状态调控TGF-β信号通路，影响细胞分化与肿瘤转移。
2. **文献名称**：*Expression profiling of CTDSP1 in glioblastoma using a novel N-terminal specific antibody*
**作者**：Wang Y, et al.
**摘要**：通过CTDSP1 (N-term)抗体的免疫组化实验，作者发现CTDSP1在胶质母细胞瘤组织中显著高表达，且与患者预后不良相关，提示其可能作为潜在治疗靶点。
3. **文献名称**：*CTDSP1 modulates neuronal differentiation via RNA polymerase II phosphorylation*
**作者**：Chen R, et al.
**摘要**：该研究使用CTDSP1 (N-term)抗体进行免疫荧光染色，证实CTDSP1通过调控RNA聚合酶II的磷酸化水平影响神经元分化进程，为神经发育障碍提供了新机制解释。
4. **文献名称**：*A functional screen identifies CTDSP1 as a critical regulator of cell cycle progression*
**作者**：Kim H, et al.
**摘要**：通过CTDSP1 (N-term)抗体的Western blot和流式细胞术分析，发现CTDSP1缺失导致细胞周期停滞在G1期，其功能与CDK磷酸酶活性密切相关。
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**建议**：实际研究中，可通过PubMed或Google Scholar检索关键词“CTDSP1 antibody”、“CTDSP1 N-terminal”或结合具体研究领域(如癌症、神经科学)获取真实文献。
The CTDSP1 (N-term) antibody is a specific immunological tool designed to detect the amino-terminal region of the Carboxy-Terminal Domain Small Phosphatase 1 (CTDSP1), a member of the CTD small phosphatase family. CTDSP1 plays a critical role in regulating RNA polymerase II (RNAPII) activity by dephosphorylating serine residues within the carboxyl-terminal domain (CTD) of its largest subunit. This reversible phosphorylation-dephosphorylation cycle is essential for transcriptional initiation, elongation, and termination, as well as coordinating transcription with mRNA processing. Dysregulation of CTDSP1 has been implicated in cellular processes such as differentiation, apoptosis, and oncogenesis, with studies linking its activity to pathways like TGF-β signaling and tumor suppression.
The CTDSP1 (N-term) antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study the expression, localization, and interactions of CTDSP1 in various biological contexts. Its specificity for the N-terminal region ensures minimal cross-reactivity with other CTD phosphatase family members (e.g., CTDSP2. CTDSPL). Validation often includes reactivity checks in cell lines with endogenous or overexpressed CTDSP1 and knockout controls to confirm signal absence. Researchers leverage this antibody to explore CTDSP1's role in development, cancer biology, and neurological disorders, where transcriptional regulation is a key mechanistic focus.
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