Rabbit Polyclonal TESK1 Antibody

The TESK1 (testis-specific kinase 1) antibody is a tool used to detect and study the TESK1 protein, a serine/threonine kinase belonging to the LIM kinase superfamily. Initially identified for its testis-enriched expression, TESK1 is now recognized to play roles in cytoskeletal dynamics by regulating cofilin, an actin-depolymerizing protein. Unlike its homolog TESK2. TESK1 is broadly expressed in tissues, including the brain, immune cells, and cancer cells, though its name reflects its initial discovery in germ cells. TESK1 phosphorylates cofilin, inhibiting its actin-severing activity and influencing cell motility, adhesion, and morphogenesis. Its involvement in signaling pathways, such as TGF-β and integrin-mediated pathways, links it to processes like cancer metastasis, immune regulation, and neuronal development. Antibodies against TESK1 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore its localization, expression levels, and interactions in physiological and pathological contexts. Research utilizing TESK1 antibodies has highlighted its dual kinase activity (serine/threonine and tyrosine phosphorylation) and crosstalk with other kinases, such as LIMK1/2. These studies also suggest TESK1 as a potential therapeutic target in diseases involving aberrant cytoskeletal remodeling, including fibrosis and cancer. Validation of TESK1 antibodies often includes knockout controls to confirm specificity, given its structural similarities to other kinases.