Rabbit Polyclonal EDG4(N-term) Antibody

The EDG4 (N-term) antibody is designed to target the N-terminal region of the Endothelial Differentiation Gene 4 (EDG4), also known as sphingosine-1-phosphate receptor 1 (S1PR1). S1PR1 is a G protein-coupled receptor (GPCR) that binds sphingosine-1-phosphate (S1P), a bioactive lipid mediator involved in regulating cellular processes such as proliferation, migration, and angiogenesis. This receptor plays a critical role in immune cell trafficking, vascular development, and inflammatory responses. The EDG4 (N-term) antibody is commonly used in research to detect and quantify S1PR1 expression in various biological samples via techniques like Western blotting, immunohistochemistry, and flow cytometry. Its specificity for the N-terminal domain ensures recognition of full-length or appropriately processed forms of the receptor, aiding studies on receptor localization, trafficking, and signaling. Dysregulation of S1PR1 is linked to pathologies including cancer, autoimmune diseases, and vascular disorders, making this antibody a valuable tool for investigating disease mechanisms and therapeutic targets. Researchers often validate its specificity using knockout controls or peptide blocking assays to confirm binding accuracy.