| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAP-K3, MAPKAPK-3, MK-3, Mapkapk3 |
| Entrez GeneID | 102626 |
| WB Predicted band size | 43.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Mapkapk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of mouse Mapkapk3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse MAPKAPK3 (N-term)抗体的3篇参考文献示例(注：内容为模拟，实际文献需通过数据库检索确认)：
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1. **文献名称**: *MAPKAPK3 modulates inflammatory responses via phosphorylation of c-Fos*
**作者**: Li, X. et al.
**摘要**: 本研究揭示了MAPKAPK3通过磷酸化转录因子c-Fos调控炎症信号通路的作用。作者使用针对小鼠MAPKAPK3 N端的特异性抗体，通过免疫沉淀和Western blot验证了其在巨噬细胞中的表达及相互作用。
2. **文献名称**: *Role of MAPKAPK3 in cardiac hypertrophy development*
**作者**: Zhang, Y. et al.
**摘要**: 文章探讨了MAPKAPK3在病理性心脏肥大中的功能。研究采用N端特异性小鼠抗体进行组织免疫荧光染色，发现MAPKAPK3在压力超负荷模型中的亚细胞定位变化，提示其与ERK信号串扰相关。
3. **文献名称**: *Antibody characterization of MAPKAPK3 in stress-induced cellular models*
**作者**: Gupta, R. et al.
**摘要**: 该研究系统评估了多种MAPKAPK3抗体的特异性，包括针对N端的小鼠单克隆抗体。通过敲低实验和肽段阻断验证，确认该抗体适用于流式细胞术及免疫组化，为相关疾病模型提供可靠工具。
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**建议**：实际文献可通过PubMed或Google Scholar搜索关键词“MAPKAPK3 antibody N-terminal mouse”或结合抗体货号(如产品说明书引用文献)获取。部分公司(如Cell Signaling Technology)的抗体页面会列出相关研究文献。
The Mouse MAPKAPK3 (N-term) antibody is designed to detect the N-terminal region of mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), a serine/threonine kinase involved in cellular stress and inflammatory signaling. Also known as MK3 or 3pK, MAPKAPK3 is part of the p38 MAPK signaling pathway, activated via phosphorylation by p38 MAPK in response to stressors like cytokines, heat shock, or osmotic stress. It regulates downstream targets by phosphorylating proteins involved in mRNA stability, transcription, and cytoskeletal reorganization, influencing processes such as cell proliferation, differentiation, and apoptosis.
The N-terminal domain of MAPKAPK3 contains critical regulatory motifs required for its kinase activity and interaction with upstream activators. Antibodies targeting this region are valuable tools for studying endogenous MAPKAPK3 expression, activation states, and localization in mouse-derived samples. They are widely used in applications like Western blotting, immunoprecipitation, and immunofluorescence to investigate MAPKAPK3's role in diseases such as cancer, autoimmune disorders, and chronic inflammation. Research highlights its dual cytoplasmic-nuclear shuttling ability and its crosstalk with other signaling pathways, including mTOR and PI3K/AKT. This antibody aids in elucidating MAPKAPK3's complex regulatory mechanisms and its potential as a therapeutic target.
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