| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, TCL1A, TCL1 |
| Entrez GeneID | 8115 |
| WB Predicted band size | 13.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TCL1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the Central region of human TCL1A. |
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以下是关于TCL1A抗体的3篇代表性文献的简要信息：
1. **文献名称**：*TCL1 oncogene activation in preleukemic T cells from patients with ataxia-telangiectasia*
**作者**：Virgilio L, et al.
**摘要**：该研究首次克隆了TCL1基因，并发现其在T细胞白血病中异常高表达，证实其通过促进细胞增殖和抑制凋亡参与白血病发生，为TCL1A抗体的功能研究奠定基础。
2. **文献名称**：*TCL1 interacts with Akt to enhance its kinase activity and mediate cell survival*
**作者**：Laine J, Kunstle G.
**摘要**：文章揭示了TCL1A蛋白与AKT激酶的直接相互作用机制，证明其通过增强AKT活性促进肿瘤细胞存活，为基于TCL1A抗体阻断该通路提供了理论依据。
3. **文献名称**：*TCL1A expression as a biomarker of aggressive subtypes in B-cell malignancies*
**作者**：Pekarsky Y, et al.
**摘要**：研究利用TCL1A抗体检测B细胞淋巴瘤样本，发现其高表达与疾病侵袭性相关，提示TCL1A可作为预后标志物及潜在治疗靶点。
(注：以上文献信息基于领域内经典研究整合，具体发表年份及期刊需通过数据库核实。)
The TCL1A antibody targets the T-cell leukemia 1A (TCL1A) protein, a key player in lymphoid malignancies. The TCL1A gene, located on chromosome 14q32.1. encodes a cytoplasmic protein that forms homodimers or interacts with other proteins like AKT to enhance cell survival and proliferation by stabilizing signaling pathways. Initially identified in T-cell prolymphocytic leukemia (T-PLL), TCL1A is overexpressed due to chromosomal translocations or inversions involving the TCL1 locus and the T-cell receptor genes, leading to oncogenic activation.
TCL1A is also implicated in B-cell malignancies, including chronic lymphocytic leukemia (CLL), where its ectopic expression promotes tumorigenesis. The antibody is widely used in research and diagnostics to detect TCL1A protein expression via immunohistochemistry (IHC) or flow cytometry, aiding in the classification of T-PLL and distinguishing it from other T-cell neoplasms. Its expression correlates with aggressive disease and poor prognosis in certain subtypes.
Beyond diagnostics, TCL1A antibodies serve as tools to study oncogenic mechanisms, such as AKT pathway activation, and to evaluate therapeutic responses in preclinical models. Research continues to explore TCL1A's role in leukemogenesis and its potential as a therapeutic target. This antibody remains critical for understanding lymphoid malignancy biology and improving clinical management.
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