| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tyrosine-protein kinase Fyn, Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, SLK, p59-Fyn, FYN |
| Entrez GeneID | 2534 |
| WB Predicted band size | 60.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FYN antibody is generated from a mouse immunized with a recombinant preotein from human FYN. |
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以下是关于FYN抗体的3篇代表性文献及其摘要概述：
1. **文献名称**：*Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease*
**作者**：Suzuki, T., et al.
**摘要**：研究利用FYN抗体检测发现，FYN激酶在阿尔茨海默病模型中通过调控tau蛋白磷酸化及淀粉样蛋白β的毒性作用，导致突触功能障碍和认知能力下降，提示FYN是潜在治疗靶点。
2. **文献名称**：*Regulation of FYN by Lipid Modification and Membrane Localization*
**作者**：Resh, M.D.
**摘要**：通过FYN抗体免疫印迹分析，揭示了FYN激酶通过棕榈酰化修饰锚定于细胞膜脂筏区，调控其在T细胞受体信号传导中的作用，为FYN亚细胞定位机制提供了关键证据。
3. **文献名称**：*FYN Expression in B-Cell Malignancies: A Novel Therapeutic Target*
**作者**：Nylander, S., et al.
**摘要**：利用FYN抗体筛选白血病样本发现，FYN在慢性淋巴细胞白血病(CLL)中异常高表达，抑制FYN活性可诱导癌细胞凋亡，提示其作为B细胞肿瘤治疗靶点的潜力。
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**备注**：以上文献为示例，实际引用时需核实具体发表信息。如需近期研究，可补充检索关键词“FYN antibody cancer/neuroscience” + “年份过滤(如2020-2023)”获取最新进展。
FYN antibody is a crucial tool in studying the FYN protein, a non-receptor tyrosine kinase belonging to the SRC family. FYN plays pivotal roles in signal transduction pathways, particularly in T-cell receptor signaling, neuronal development, and synaptic plasticity. It contains SH2 and SH3 domains that mediate protein-protein interactions, enabling its involvement in diverse cellular processes, including cell adhesion, proliferation, and differentiation. Dysregulation of FYN is linked to pathologies such as cancer, Alzheimer’s disease, and autoimmune disorders. In Alzheimer’s, FYN interacts with tau and amyloid-beta, contributing to neurotoxicity.
FYN antibodies are widely used in research to detect FYN expression, phosphorylation status, and localization via techniques like Western blotting, immunohistochemistry, and flow cytometry. They help elucidate FYN’s role in signaling cascades (e.g., PI3K/AKT, MAPK) and its crosstalk with other kinases. Both monoclonal and polyclonal FYN antibodies are available, targeting specific regions like the N-terminus or kinase domain. Validation of these antibodies is critical, as FYN shares homology with other SRC kinases. Recent studies also explore FYN inhibitors and their therapeutic potential, highlighting the antibody’s dual role in basic research and drug development. Its applications extend to studying immune responses, neurodegeneration, and cancer metastasis mechanisms.
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