| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fanconi anemia group C protein, Protein FACC, FANCC, FAC, FACC |
| Entrez GeneID | 2176 |
| WB Predicted band size | 63.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FANCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 527-555 amino acids from the C-terminal region of human FANCC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FANCC抗体的3篇参考文献及其摘要概述：
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1. **文献名称**: "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway"
**作者**: Taniguchi, T., D'Andrea, A.D.
**摘要**: 研究揭示了FANCC蛋白与BRCA1在DNA损伤修复通路中的协同作用，利用FANCC抗体验证了其在FA/BRCA通路中的功能，表明FANCC缺失会导致基因组不稳定性和癌症易感性。
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2. **文献名称**: "The Fanconi anemia protein FANCC is required for the nuclear localization of FANCD2"
**作者**: Garcia-Higuera, I., et al.
**摘要**: 通过免疫荧光和Western blot实验(使用FANCC抗体)，证明FANCC对FANCD2的核定位至关重要，并阐明了其在维持DNA损伤修复复合体完整性中的作用。
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3. **文献名称**: "A comprehensive review of Fanconi anemia signaling and its therapeutic implications"
**作者**: Walsh, C.S., et al.
**摘要**: 综述中总结了FANCC抗体的应用，包括检测患者细胞中FANCC蛋白表达水平及突变分析，为Fanconi贫血的分子诊断提供了实验依据。
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如需具体实验细节或更新文献，建议通过PubMed或Google Scholar以“FANCC antibody”为关键词进一步检索。
The FANCC antibody is a crucial tool for studying the FANCC protein, a key component of the Fanconi anemia (FA) core complex within the FA/BRCA DNA repair pathway. This pathway is essential for repairing DNA interstrand crosslinks (ICLs) and maintaining genomic stability. FANCC, encoded by the *FANCC* gene, interacts with other FA proteins (e.g., FANCA, FANCG) to form a ubiquitin ligase complex that monoubiquitinates FANCD2/FANCI, triggering downstream repair processes. Mutations in *FANCC* are linked to Fanconi anemia, a rare autosomal recessive disorder characterized by bone marrow failure, congenital abnormalities, and heightened cancer susceptibility, particularly acute myeloid leukemia.
FANCC antibodies are widely used to detect FANCC protein expression and localization in cells or tissues via techniques like Western blotting, immunofluorescence, and immunoprecipitation. They help elucidate FANCC's role in DNA damage responses, hematopoietic stem cell function, and tumor suppression. Researchers also employ these antibodies to study disease mechanisms in FA patient-derived cells, evaluate the impact of *FANCC* mutations, and explore therapeutic strategies targeting FA pathway deficiencies. Commercial FANCC antibodies are typically raised against specific epitopes, ensuring specificity for endogenous FANCC. Their application advances understanding of FA biology, cancer predisposition, and potential interventions to restore DNA repair capacity in FA-related pathologies.
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