Mouse Monoclonal CCRK(N-term) Antibody

The CCRK (Cell Cycle-Related Kinase) antibody targeting the N-terminal region is a tool used to study the protein encoded by the *CCRK* gene (also known as *CDK20*), which belongs to the cyclin-dependent kinase (CDK)-related kinase family. CCRK is involved in regulating cell cycle progression, transcriptional modulation, and signaling pathways such as the Wnt/β-catenin cascade. The N-terminal domain of CCRK contains conserved structural motifs critical for kinase activity and protein-protein interactions. This antibody is typically raised in rabbits or mice using synthetic peptides or recombinant proteins corresponding to the N-terminal region, enabling specificity in detecting endogenous CCRK across applications like Western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CCRK has been implicated in various cancers, including hepatocellular carcinoma and glioblastoma, where its overexpression correlates with tumor growth and poor prognosis. Researchers use the CCRK (N-term) antibody to investigate its role in cell cycle checkpoints, cilia function, and disease mechanisms, particularly in contexts of carcinogenesis and developmental disorders. Validation often includes knockout controls or siRNA-mediated silencing to confirm target specificity. Its utility extends to both basic research and preclinical studies exploring CCRK as a potential therapeutic target.