| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 40S ribosomal protein S21, RPS21 |
| Entrez GeneID | 6227 |
| WB Predicted band size | 9.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This RPS21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-71 amino acids from the C-terminal region of human RPS21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RPS21抗体的参考文献示例(注：以下内容为模拟生成，非真实文献)：
1. **"RPS21 expression in colorectal cancer: a potential biomarker for prognosis"**
- **作者**: Zhang, L. et al.
- **摘要**: 研究通过免疫组化(使用抗RPS21抗体)分析结直肠癌组织中RPS21的表达水平，发现其高表达与患者生存率降低显著相关，提示RPS21可能作为预后标志物。
2. **"RPS21 regulates breast cancer cell proliferation via the mTOR pathway"**
- **作者**: Li, X. et al.
- **摘要**: 利用抗RPS21抗体进行Western blot和免疫荧光实验，发现RPS21通过激活mTOR信号通路促进乳腺癌细胞增殖，敲低RPS21显著抑制肿瘤生长。
3. **"RPS21 interacts with hepatitis B virus core protein and promotes viral replication"**
- **作者**: Wang, Y. et al.
- **摘要**: 研究通过免疫共沉淀(使用抗RPS21抗体)发现RPS21与乙肝病毒核心蛋白相互作用，促进病毒复制，为抗病毒治疗提供新靶点。
4. **"Proteomic analysis identifies RPS21 as a novel target in acute myeloid leukemia"**
- **作者**: Chen, H. et al.
- **摘要**: 采用抗RPS21抗体进行蛋白质组学分析，发现RPS21在急性髓系白血病中异常高表达，且与化疗耐药性相关，可能成为治疗靶点。
(注意：以上文献为假设性示例，实际研究中请通过PubMed或Web of Science等平台检索具体文献。)
RPS21 antibody targets the ribosomal protein S21. a component of the 40S ribosomal subunit involved in protein synthesis. Encoded by the RPS21 gene located on human chromosome 20 (20q13.33), this protein plays a critical role in mRNA translation initiation and elongation. Beyond its canonical ribosomal function, RPS21 has been implicated in extra-ribosomal activities, including cellular stress responses, apoptosis regulation, and DNA repair pathways. Dysregulation of RPS21 expression is associated with various cancers, such as colorectal, breast, and hepatocellular carcinomas, where its overexpression often correlates with tumor progression and poor prognosis.
RPS21 antibodies are widely used in research to investigate ribosome biogenesis, translational control mechanisms, and cancer biology. They enable detection and localization of RPS21 via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Some studies also explore RPS21's potential as a diagnostic or prognostic biomarker. Polyclonal and monoclonal variants of these antibodies are generated using recombinant RPS21 protein or peptide antigens, with validation typically including knockout cell lines or siRNA-mediated silencing to confirm specificity. Recent interest focuses on RPS21's interaction with viral RNAs and its role in infection processes, expanding its relevance in virology and immunology research.
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