Rabbit Polyclonal DANREhmx3 Antibody

The DANRE HMX3 antibody is a tool used to study the HMX3 protein in the zebrafish model (*Danio rerio*). HMX3 belongs to the HMX family of homeodomain-containing transcription factors, which play critical roles in embryonic development, particularly in the nervous system and sensory organs. In zebrafish, HMX3 is implicated in the development of the anterior nervous system, including the forebrain and retinal regions, as well as the formation of sensory structures like the otic vesicles (ear precursors). Researchers use the HMX3 antibody to detect and localize the protein via techniques such as immunohistochemistry, immunofluorescence, and Western blotting, enabling insights into its expression patterns and regulatory functions during embryogenesis. The antibody is typically raised in host species like rabbits or mice, targeting specific epitopes of the HMX3 protein. Its development has supported studies on gene knockout or morpholino-mediated knockdown models, linking HMX3 dysfunction to developmental abnormalities, such as defects in cranial ganglia or vision-related structures. These findings contribute to broader understanding of neurodevelopmental mechanisms and potential human disorders associated with HMX gene family mutations.