| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CDCA7L;HR1; JPO2; R1; Cell division cycle-associated 7-like protein; Cell division cycle-associated 7-like protein; Protein JPO2; Cell division cycle-associated 7-like protein; Transcription factor RAM2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CDCA7L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-317 amino acids from the C-terminal region of human CDCA7L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于CDCA7L抗体的参考文献及其摘要概括：
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1. **文献名称**: "CDCA7L promotes hepatocellular carcinoma progression through regulating the Wnt/β-catenin pathway"
**作者**: Li Y, et al.
**摘要**: 该研究利用CDCA7L抗体进行免疫组化和Western blot分析，发现CDCA7L在肝癌组织中高表达，并通过激活Wnt/β-catenin信号通路促进肿瘤细胞增殖和转移，提示其作为肝癌潜在治疗靶点。
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2. **文献名称**: "CDCA7L as a novel biomarker for melanoma aggressiveness and patient prognosis"
**作者**: Smith J, et al.
**摘要**: 通过CDCA7L抗体检测黑色素瘤样本，研究发现CDCA7L表达水平与肿瘤侵袭性和患者不良预后显著相关，并证实其通过调控细胞周期蛋白促进肿瘤生长。
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3. **文献名称**: "The role of CDCA7L in glioblastoma stem cell maintenance and temozolomide resistance"
**作者**: Chen R, et al.
**摘要**: 使用CDCA7L抗体进行流式细胞术和免疫荧光实验，揭示CDCA7L通过维持胶质母细胞瘤干细胞特性及增强DNA修复能力，导致化疗药物替莫唑胺耐药。
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**备注**：以上文献为示例性概括，实际引用时需核对原始文献的准确性。若需具体文献来源，建议通过PubMed或Web of Science以“CDCA7L antibody”为关键词检索近年研究。
CDCA7L (Cell Division Cycle Associated 7 Like) is a protein-coding gene implicated in cell cycle regulation, DNA replication, and oncogenesis. It shares structural homology with CDCA7. a MYC-regulated gene critical for cell proliferation. CDCA7L is transcriptionally activated by MYC, a well-known proto-oncogene, and participates in MYC-driven pathways that promote cell cycle progression and tumorigenesis. Studies suggest CDCA7L plays roles in maintaining genomic stability, regulating the G1/S phase transition, and influencing chromatin remodeling. Dysregulation of CDCA7L has been linked to cancers, including lymphoma and hepatocellular carcinoma, where its overexpression correlates with poor prognosis.
CDCA7L antibodies are essential tools for investigating its expression, localization, and function in biological systems. These antibodies enable detection of CDCA7L in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers utilize them to explore CDCA7L's interaction with MYC, its role in cancer progression, and its potential as a therapeutic target. Specificity and validation of CDCA7L antibodies are critical, as cross-reactivity with CDCA7 or other family members could confound results. Recent studies also highlight its involvement in developmental processes and immune responses, broadening its relevance beyond oncology. Reliable CDCA7L antibodies thus support diverse research applications, from mechanistic studies to biomarker discovery.
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