| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CDK5 and ABL1 enzyme substrate 2, Interactor with CDK3 2, Ik3-2, CABLES2, C20orf150 |
| Entrez GeneID | 81928 |
| WB Predicted band size | 52.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CABLES2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-210 amino acids from the Central region of human CABLES2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CABLES2抗体相关的文献摘要信息：
1. **文献名称**: "CABLES2 controls Wnt/β-catenin signaling in zebrafish neurogenesis through a negative feedback loop"
**作者**: Li Y, et al.
**摘要**: 研究利用CABLES2抗体验证斑马鱼神经发育中该蛋白的表达模式，发现其通过抑制Wnt信号通路调控神经干细胞分化，揭示其负反馈机制。
2. **文献名称**: "CABLES2 deficiency impairs embryonic neurogenesis and contributes to intellectual disability"
**作者**: Smith J, et al.
**摘要**: 通过免疫组化(使用CABLES2抗体)发现CABLES2基因缺失导致小鼠胚胎大脑皮层神经元分化异常，提示其在智力障碍疾病中的潜在作用。
3. **文献名称**: "Proteomic analysis identifies CABLES2 as a novel interacting partner of CDK3 in cell cycle regulation"
**作者**: Chen H, et al.
**摘要**: 采用CABLES2抗体进行免疫共沉淀实验，证实CABLES2与CDK3直接结合，调控G1/S期转换，为癌症治疗提供新靶点。
4. **文献名称**: "CABLES2 expression correlates with chemoresistance in ovarian cancer"
**作者**: Wang L, et al.
**摘要**: 通过Western blot(CABLES2抗体)及临床样本分析，发现CABLES2高表达与卵巢癌患者顺铂耐药性相关，可能通过PI3K/AKT通路介导。
注：以上文献信息为示例性概括，实际文献需通过PubMed或学术数据库检索具体标题及作者。
The CABLES2 (Cdk5 and Abl enzyme substrate 2) antibody is a research tool used to detect and study the CABLES2 protein, a member of the CABLES family involved in cell cycle regulation and transcriptional control. CABLES2 acts as a scaffold protein, interacting with cyclin-dependent kinases (CDKs) and other signaling molecules to modulate cell cycle progression, particularly at the G1/S checkpoint. It is implicated in maintaining genomic stability and regulating apoptosis, with emerging roles in cancer biology, neurodegeneration, and developmental processes.
Developed for experimental applications like Western blotting, immunohistochemistry, and immunofluorescence, CABLES2 antibodies help researchers investigate its expression patterns, subcellular localization, and interactions under physiological and pathological conditions. Studies suggest CABLS2 may function as a tumor suppressor in certain cancers, with reduced expression linked to poor prognosis. Its involvement in CDK5-mediated pathways also connects it to neurological disorders.
Commercial CABLES2 antibodies are typically raised in hosts like rabbits or mice, validated for specificity through knockout controls or siRNA knockdown. Some variants detect post-translational modifications, such as phosphorylation sites critical for its regulatory functions. Ongoing research using these antibodies aims to clarify CABLES2's mechanistic roles in disease and its potential as a therapeutic target.
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