关键信息
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基因名
gabT
- 应用
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别名
((S)-3-amino-2-methylpropionate transaminase)(GABA aminotransferase)(GABA-AT)(Gamma-amino-N-butyrate transaminase)(GABA transaminase)(Glutamate:succinic semialdehyde transaminase)(L-AIBAT)
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种属
Mycobacterium bovis
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P63505
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表达区间
1-449aa
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分子量
54.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GabT protein, or GABA transaminase, plays a crucial role in the metabolism of gamma-aminobutyric acid (GABA), a significant neurotransmitter in the central nervous system. GABA has notable implications in regulating neuronal excitability and maintaining the balance between excitation and inhibition in neurological processes. Dysregulation of GABA levels has been implicated in various neurological disorders, including epilepsy, anxiety disorders, and depression. Research focused on GabT aims to elucidate its enzymatic functions, structure, and regulation, ultimately aiding in the development of therapeutic strategies targeting related disorders. The recombinant expression and purification of GabT enable comprehensive studies of its biochemical properties and interactions, facilitating the design of inhibitors or modulators that could serve as potential treatments for GABA-related conditions. By exploring the enzymatic mechanisms and the physiological relevance of GabT, researchers hope to contribute to a more profound understanding of GABAergic signaling pathways and their impact on brain function and behavior. This line of research is essential for uncovering novel pharmacological targets and advancing therapeutic options for managing GABAergic dysfunctions.
