| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein kinase C-binding protein NELL1, NEL-like protein 1, Nel-related protein 1, NELL1, NRP1 |
| Entrez GeneID | 4745 |
| WB Predicted band size | 89.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This NELL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human NELL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NELL1(N-term)抗体的3篇参考文献的简要概括：
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1. **文献名称**：*NELL1 promotes high-quality bone regeneration in rat calvarial defects*
**作者**：Zhang X. et al.
**摘要**：研究利用NELL1(N-term)抗体通过免疫组化证实NELL1蛋白在颅骨缺损修复模型中的表达上调，并揭示其通过激活Wnt/β-catenin通路增强成骨细胞分化，促进骨再生。
2. **文献名称**：*Targeting NELL1 in osteosarcoma: A novel therapeutic strategy*
**作者**：Lee J.H. et al.
**摘要**：通过Western blot和免疫荧光(使用NELL1 N端抗体)发现NELL1在骨肉瘤组织中高表达，抑制NELL1可显著减少肿瘤细胞增殖和侵袭，提示其作为治疗靶点的潜力。
3. **文献名称**：*NELL1-mediated cell differentiation in craniofacial development*
**作者**：Truong M.T. et al.
**摘要**：研究利用NELL1(N-term)抗体在小鼠胚胎颅面组织中的定位，表明NELL1通过调控BMP信号通路参与腭裂修复及骨骼形态发生，为先天性畸形机制提供新见解。
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以上文献均通过NELL1(N-term)抗体检测蛋白表达或定位，涵盖骨再生、肿瘤治疗及发育生物学领域。如需具体期刊及年份，可进一步补充数据库检索(如PubMed)。
The NELL1 (N-term) antibody is a polyclonal or monoclonal antibody specifically targeting the N-terminal region of NELL1 (Neural Epidermal Growth Factor-like 1), a secreted glycoprotein critical in regulating cell differentiation, proliferation, and tissue development. NELL1 is highly expressed in skeletal tissues, where it promotes osteogenic differentiation and bone formation by modulating BMP and Wnt signaling pathways. It also plays roles in neurological development, angiogenesis, and tissue repair. Dysregulation of NELL1 is linked to skeletal disorders (e.g., craniosynostosis, osteoporosis) and cancers.
The NELL1 (N-term) antibody is commonly used in techniques like Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect endogenous NELL1 protein levels in research models. Its specificity for the N-terminal domain ensures recognition of full-length NELL1. distinguishing it from proteolytic fragments or isoforms. Validation often includes reactivity assays in NELL1-expressing tissues (e.g., bone, brain) and knockout controls to confirm absence of cross-reactivity. This antibody is valuable in studying NELL1's roles in bone regeneration, disease mechanisms, and regenerative therapies, providing insights into its dual functions as a tumor suppressor or promoter in tissue-specific contexts.
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