| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cellular nucleic acid-binding protein, CNBP, Zinc finger protein 9, CNBP, RNF163, ZNF9 |
| Entrez GeneID | 7555 |
| WB Predicted band size | 19.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CNBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-118 amino acids from the Central region of human CNBP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CNBP抗体的3篇参考文献示例(文献信息为模拟内容，仅供参考)：
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1. **文献名称**: *CNBP regulates ribosomal RNA expression and muscle cell differentiation*
**作者**: Smith A, et al.
**摘要**: 本研究利用CNBP特异性抗体通过免疫沉淀和Western blot技术，揭示了CNBP蛋白在调控核糖体RNA合成中的关键作用，并发现其在肌肉细胞分化过程中表达水平显著上调，提示其可能参与肌肉疾病的分子机制。
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2. **文献名称**: *Autoantibodies against CNBP in Myotonic Dystrophy Type 2 patients*
**作者**: Lee J, et al.
**摘要**: 通过ELISA和免疫荧光技术，研究者发现Ⅱ型强直性肌营养不良患者血清中存在针对CNBP的自身抗体。文章提出这些抗体可能干扰CNBP的正常功能，导致RNA剪接异常，为疾病诊断提供了潜在生物标志物。
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3. **文献名称**: *Subcellular localization of CNBP in neuronal cells*
**作者**: García-Ruiz C, et al.
**摘要**: 使用抗CNBP抗体进行免疫细胞化学分析，发现CNBP主要定位于细胞核及胞质应激颗粒中，且在氧化应激条件下易发生聚集。研究提示CNBP可能参与神经退行性病变中的应激反应通路。
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**备注**：实际文献需通过PubMed或Google Scholar检索关键词(如“CNBP antibody”、“ZNF9 antibody”)获取。若需具体文献，建议补充研究背景或应用方向(如疾病模型、实验技术等)。
The cellular nucleic acid-binding protein (CNBP), also known as zinc finger protein 9 (ZNF9), is a conserved nucleic acid-binding protein with roles in transcriptional and translational regulation. Structurally, CNBP contains seven zinc finger domains of the CCHC type, enabling its interaction with DNA, RNA, and G-rich sequences. It is ubiquitously expressed in mammalian tissues, particularly in the brain, heart, and skeletal muscle. Functionally, CNBP is implicated in ribosome biogenesis, mRNA stability, and translational control, influencing cellular processes like proliferation, differentiation, and stress response.
Mutations in the CNBP gene are linked to myotonic dystrophy type 2 (DM2), a multisystemic disorder characterized by muscle weakness, cataracts, and cardiac arrhythmias. Expanded CCTG repeats in the first intron of CNBP lead to toxic RNA aggregates, disrupting RNA metabolism. CNBP antibodies are critical tools for studying its expression, subcellular localization (primarily cytoplasmic), and molecular interactions. They are used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore its role in disease mechanisms, RNA metabolism, and stress granule dynamics. Researchers must validate antibody specificity due to potential cross-reactivity with other zinc finger proteins. Current studies focus on CNBP’s involvement in neurodegeneration, cancer, and its regulatory interplay with non-coding RNAs.
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