| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Keratin, type II cuticular Hb6, Hair keratin K211, Keratin-86, K86, Type II hair keratin Hb6, Type-II keratin Kb26, KRT86, KRTHB6 |
| Entrez GeneID | 3892 |
| WB Predicted band size | 53.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This KRT86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于KRT86抗体的3篇示例文献(注：内容为模拟虚构，仅供参考)：
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**1. 文献名称**
"KRT86 as a Potential Biomarker in Androgenetic Alopecia: Immunohistochemical Analysis Using a Novel Monoclonal Antibody"
**作者**
Smith J, Lee R, et al.
**摘要**
本研究开发了一种特异性识别KRT86蛋白的单克隆抗体，并验证其在雄激素性脱发患者毛囊组织中的表达差异。通过免疫组化分析发现，KRT86在脱发区域毛囊中的表达显著下调，提示其可能参与毛干结构稳定性调控。
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**2. 文献名称**
"Characterization of Anti-KRT86 Antibody for Differential Diagnosis of Hereditary Hair Shaft Disorders"
**作者**
Zhang Y, Wang H, et al.
**摘要**
该研究利用兔源多克隆KRT86抗体，对遗传性毛发结构异常患者的头皮样本进行蛋白质印迹和免疫荧光检测。结果表明，KRT86表达缺失与特定类型的毛干畸形相关，为临床诊断提供了分子标志物。
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**3. 文献名称**
"KRT86 Expression in Cutaneous Squamous Cell Carcinoma: Insights from Antibody-Based Proteomic Profiling"
**作者**
Garcia M, Patel S, et al.
**摘要**
通过构建组织芯片并使用KRT86抗体进行高通量免疫组化分析，发现皮肤鳞状细胞癌(cSCC)中KRT86蛋白异常高表达，且与肿瘤侵袭性正相关，提示其可能作为预后评估的辅助指标。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“KRT86 antibody”或“anti-KRT86”，并结合具体研究领域筛选。
The KRT86 antibody targets keratin 86. a type II intermediate filament protein encoded by the *KRT86* gene (also known as *KRTHB6*). Keratin 86 is predominantly expressed in hair follicles and hard keratinized tissues, playing a critical role in maintaining structural integrity and mechanical resilience of hair shafts. It pairs with specific type I keratins (e.g., KRT31-34) to form heteropolymers, essential for hair fiber formation and stability. Mutations in *KRT86* are linked to hereditary hair disorders, such as monilethrix and pseudomonilethrix, characterized by brittle hair and follicular hyperkeratosis.
KRT86 antibodies are widely used in research to study hair biology, genetic hair diseases, and epithelial differentiation. They enable localization of KRT86 in tissues via immunohistochemistry (IHC) or immunofluorescence (IF) and detect protein expression levels through Western blotting. Commercial antibodies are typically raised in rabbits or mice using recombinant protein fragments or synthetic peptides. Validation includes testing on keratinocyte cultures or hair follicle sections. Recent studies also explore KRT86's potential role in epithelial cancers, though its diagnostic or therapeutic relevance remains under investigation. Proper antibody validation remains crucial due to cross-reactivity risks with other keratins.
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