Rabbit Polyclonal HIST2H2AC Antibody

The HIST2H2AC antibody targets a specific histone protein, H2A clustered histone 2 (H2AC2), encoded by the HIST2H2AC gene in humans. Histones are essential nuclear proteins that organize DNA into nucleosomes, the fundamental units of chromatin. The H2A family includes multiple variants, with HIST2H2AC being a core component involved in maintaining chromatin structure and regulating gene expression. This histone plays a role in DNA repair, replication, and epigenetic modifications through post-translational changes such as acetylation, phosphorylation, or ubiquitination. Antibodies against HIST2H2AC are widely used in research to investigate histone dynamics, nucleosome remodeling, and epigenetic mechanisms in cellular processes. They are applied in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study histone modification patterns, chromatin accessibility, and their implications in diseases such as cancer. Dysregulation of HIST2H2AC or its modifications has been linked to transcriptional abnormalities and genomic instability. Researchers also utilize these antibodies to explore developmental biology, stem cell differentiation, and responses to DNA-damaging agents. Commercial HIST2H2AC antibodies are typically validated for specificity across species (human, mouse, rat) and tested for cross-reactivity with other H2A variants to ensure precision in experimental outcomes.