首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal ZNF101(Center) Antibody

  • 中文名: ZNF101(Center)抗体
  • 别    名: Zinc finger protein 101, Zinc finger protein HZF12, ZNF101
货号: IPDX32236
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger protein 101, Zinc finger protein HZF12, ZNF101
Entrez GeneID94039
WB Predicted band size50.3kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ZNF101 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-148 amino acids from the Central region of human ZNF101.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是关于ZNF101(Center)抗体的3篇参考文献的简要概括(注:以下内容为模拟生成,实际文献可能需要通过学术数据库查询):

---

1. **文献名称**: *ZNF101 interacts with histone deacetylases to regulate transcriptional repression in cancer cells*

**作者**: Smith J, et al.

**摘要**: 本研究利用针对ZNF101中心结构域的特异性抗体,通过免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)技术,发现ZNF101通过与组蛋白去乙酰化酶(HDACs)结合,参与调控癌症相关基因的表观遗传沉默。抗体在Western blot中显示高特异性,验证了ZNF101在多种癌细胞系中的表达。

2. **文献名称**: *Characterization of a novel monoclonal antibody against the central zinc finger domain of ZNF101*

**作者**: Lee H, et al.

**摘要**: 文章报道了一种针对ZNF101蛋白中心锌指结构域的单克隆抗体的开发与验证。通过ELISA和免疫荧光实验证实该抗体可特异性识别重组和人源细胞中的ZNF101.并成功应用于组织微阵列分析,揭示ZNF101在正常与肿瘤组织中的差异表达模式。

3. **文献名称**: *ZNF101 modulates neuronal differentiation via binding to promoter regions of target genes*

**作者**: Garcia R, et al.

**摘要**: 研究使用ZNF101(Center)抗体进行ChIP-seq分析,发现ZNF101在神经干细胞分化过程中结合多个神经发育相关基因的启动子区域,调控其转录活性。抗体的特异性通过siRNA敲低实验和质谱分析得到验证,支持ZNF101在神经分化中的关键作用。

---

如需具体文献,建议在PubMed或Google Scholar中以关键词“ZNF101 antibody”、“ZNF101 epitope”或“ZNF101 function”进行检索,并筛选涉及抗体应用的实验研究。

背景信息

ZNF101 (Center) antibody is designed to target the central region of the Zinc Finger Protein 101 (ZNF101), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZNF) family. These proteins are characterized by tandem arrays of C2H2-type zinc finger motifs, which mediate sequence-specific DNA binding, and a KRAB domain that often recruits transcriptional corepressors. ZNF101 is thought to play roles in transcriptional regulation, chromatin remodeling, and cellular differentiation, though its precise biological functions remain under investigation. The antibody is commonly used in research applications such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study ZNF101's expression, localization, and interaction partners. Its specificity for the central region allows detection of full-length or truncated isoforms containing this domain. Validation typically includes knockout cell line controls to confirm target specificity. As aberrant expression of ZNF proteins is linked to cancer and developmental disorders, this antibody serves as a tool for exploring ZNF101's potential roles in disease pathogenesis and gene regulatory networks. Commercial versions are often raised in rabbits or mice, with epitope sequences corresponding to conserved regions across species.

客户数据及评论

折叠内容

大包装询价

×