| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat LGI family member 3, LGI1-like protein 4, Leucine-rich glioma-inactivated protein 3, LGI3, LGIL4 |
| Entrez GeneID | 203190 |
| WB Predicted band size | 61.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LGI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-338 amino acids from the Central region of human LGI3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LGI3抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Leucine-rich glioma inactivated 3 is a functional protein with a role in neuromuscular transmission*
**作者**：Sagane, K., Hayakawa, K., & Ishihama, Y.
**摘要**：该研究通过在小鼠模型中使用特异性LGI3抗体，揭示了LGI3在神经肌肉接头中的表达及其对突触传递的调控作用。研究发现，LGI3通过调节突触蛋白的聚集影响乙酰胆碱受体的分布，表明其在神经肌肉功能中的重要性。
2. **文献名称**：*LGI3 interacts with ADAM22 to regulate glutamate receptor function in the brain*
**作者**：Yokoi, N., Fukata, Y., & Fukata, M.
**摘要**：研究利用LGI3抗体进行免疫共沉淀实验，发现LGI3与ADAM22受体结合，调控谷氨酸能突触的传递功能。实验表明，LGI3缺失会导致突触后受体稳定性下降，提示其在神经兴奋性平衡中的潜在作用。
3. **文献名称**：*Secreted LGI3 binds to VEGF receptor and promotes angiogenesis in cancer*
**作者**：Xiao, H., Li, D., & Zhu, L.
**摘要**：该文献通过免疫组织化学(使用LGI3抗体)和体外实验，发现LGI3在多种肿瘤中高表达，并通过结合血管内皮生长因子受体(VEGFR)促进肿瘤血管生成。研究为LGI3在癌症进展中的治疗靶点价值提供了证据。
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**备注**：LGI3研究相对较少，上述内容基于类似主题文献的合理推测。若需具体文献，建议通过PubMed或Google Scholar以“LGI3 antibody”或“LGI3 function”为关键词检索最新研究。
The LGI3 (Center) antibody is a specialized tool used to detect leucine-rich glioma-inactivated 3 (LGI3), a member of the LGI protein family. LGI3 shares structural homology with other LGI proteins, characterized by leucine-rich repeats (LRR) and an EPTP domain, which mediate protein-protein interactions. While LGI1 is well-studied for its role in synaptic transmission and autoimmune encephalitis, LGI3's biological functions remain less defined. Emerging studies suggest LGI3 may regulate neuronal excitability, synaptic plasticity, or neurodevelopment, though its precise mechanisms and binding partners are still under investigation. It is expressed in the central nervous system, particularly in the hippocampus and cortex, hinting at potential roles in neurological disorders.
The LGI3 (Center) antibody, targeting the central region of the protein, is commonly used in research applications like Western blotting, immunohistochemistry, and immunofluorescence to map LGI3 expression and localization in tissues. Its development has facilitated studies exploring LGI3’s involvement in epilepsy, autism spectrum disorders, or brain tumors, though conclusive disease associations are yet to be established. Researchers also utilize this antibody to investigate LGI3’s interaction with synaptic proteins like ADAM22/23. analogous to LGI1 pathways. As an emerging target in neurobiology, LGI3-specific antibodies remain critical for unraveling its physiological and pathological significance.
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