| WB | DB: 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, I-kappa-B kinase 2, IKK2, Nuclear factor NF-kappa-B inhibitor kinase beta, NFKBIKB, IKBKB, IKKB |
| Entrez GeneID | 3551 |
| WB Predicted band size | 86.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S672 of human IKKB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Phospho-IKKβ (S672)抗体的参考文献(基于模拟数据，实际文献需进一步验证)：
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1. **文献名称**: *"IKKβ phosphorylation at Ser672 regulates NF-κB activation in response to oxidative stress"*
**作者**: Li et al.
**摘要**: 研究揭示了IKKβ在Ser672位点的磷酸化在氧化应激诱导的NF-κB信号通路中的关键作用，使用Phospho-IKKβ(S672)抗体验证了该位点的修饰与炎症反应的关联。
2. **文献名称**: *"Targeted inhibition of IKKβ phosphorylation sensitizes cancer cells to apoptosis"*
**作者**: Smith et al.
**摘要**: 通过Phospho-IKKβ(S672)抗体检测发现，抑制该位点的磷酸化可增强肿瘤细胞对化疗药物的敏感性，为癌症治疗提供了新靶点。
3. **文献名称**: *"Phosphorylation dynamics of IKKβ in Toll-like receptor signaling"*
**作者**: Yamamoto et al.
**摘要**: 利用Phospho-IKKβ(S672)特异性抗体，阐明了TLR4激活后IKKβ的磷酸化级联反应，及其在先天免疫应答中的调控机制。
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**注意**：以上为示例性内容，实际文献需通过PubMed或Google Scholar检索确认。推荐使用关键词 **"IKKβ Ser672 phosphorylation antibody"** 或联系抗体供应商(如CST、Abcam)获取引用文献。
The Phospho-IKKβ (S672) antibody detects IKKβ (Inhibitor of Nuclear Factor Kappa-B Kinase subunit Beta) when phosphorylated at serine 672. a key post-translational modification linked to its activation. IKKβ, a catalytic subunit of the IKK complex (IKKα/IKKβ/IKKBγ), plays a central role in the NF-κB signaling pathway. Upon stimulation by pro-inflammatory cytokines (e.g., TNF-α, IL-1) or pathogen-associated molecules, IKKβ is activated through phosphorylation, leading to the phosphorylation and degradation of IκB proteins. This releases NF-κB transcription factors, enabling their nuclear translocation and initiation of immune, inflammatory, and survival responses.
The S672 phosphorylation site is critical for IKKβ enzymatic activity and downstream signaling. Dysregulation of this pathway is implicated in chronic inflammation, autoimmune disorders, and cancers. The Phospho-IKKβ(S672) antibody is widely used in research to study IKKβ activation dynamics, pathway regulation, and therapeutic targeting in diseases. It is validated for applications like Western blotting, immunoprecipitation, and immunofluorescence, providing specificity for the phosphorylated form over non-phosphorylated IKKβ. Researchers employ this antibody to assess drug effects, genetic knockouts, or signaling perturbations in cellular and animal models, aiding mechanistic insights into NF-κB-related pathologies.
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