| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phosphatidylethanolamine-binding protein 4, PEBP-4, hPEBP4, Protein cousin-of-RKIP 1, PEBP4, CORK1 |
| Entrez GeneID | 157310 |
| WB Predicted band size | 25.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PEBP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-127 amino acids from the Central region of human PEBP4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PEBP4抗体的3篇参考文献示例(部分信息基于文献主题整合，建议通过学术数据库核实具体内容)：
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1. **文献名称**：*PEBP4 promotes tumorigenesis and chemoresistance in breast cancer via modulating ERK signaling*
**作者**：Li Y, et al.
**摘要**：该研究通过制备特异性抗PEBP4的多克隆抗体，发现PEBP4在乳腺癌中高表达，并通过激活ERK信号通路促进肿瘤增殖和化疗耐药性。抗体用于Western blot和免疫组化验证临床样本中的蛋白表达水平。
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2. **文献名称**：*Development of a monoclonal antibody against human PEBP4 and its application in colorectal cancer diagnosis*
**作者**：Wang H, et al.
**摘要**：研究团队开发了一种针对人源PEBP4的单克隆抗体，并验证其特异性。该抗体被用于ELISA和免疫荧光检测，发现结直肠癌患者血清和组织中PEBP4水平显著升高，提示其作为潜在诊断标志物的价值。
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3. **文献名称**：*PEBP4 interacts with EGFR to sustain tumor growth in lung adenocarcinoma*
**作者**：Chen J, et al.
**摘要**：利用抗PEBP4抗体进行免疫共沉淀(Co-IP)和免疫印迹分析，揭示PEBP4与EGFR的相互作用机制。研究表明，PEBP4通过稳定EGFR信号促进肺腺癌生长，为靶向治疗提供了新思路。
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**提示**：
- 以上文献标题与内容为示例性质，实际文献需通过**PubMed**、**Web of Science**或**Google Scholar**以关键词“PEBP4 antibody”或“PEBP4 AND (therapeutic OR diagnostic)”检索。
- 部分研究可能侧重PEBP4功能而非抗体开发，建议筛选时关注抗体应用章节。
The phosphatidylethanolamine-binding protein 4 (PEBP4), a member of the PEBP family, is a conserved regulatory protein involved in modulating intracellular signaling pathways. Unlike its well-studied relative PEBP1 (RKIP), which inhibits Raf/MEK/ERK and NF-κB pathways, PEBP4 has distinct roles in cellular processes such as apoptosis, autophagy, and cancer progression. It is characterized by its ability to interact with lipid membranes and signaling molecules, influencing pathways like PI3K/AKT and MAPK. Overexpression of PEBP4 has been linked to cancer cell survival, metastasis, and resistance to chemotherapy, particularly in cancers of the breast, prostate, and liver, making it a potential therapeutic target.
PEBP4 antibodies are critical tools for studying its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available antibodies are often raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for specificity using knockdown/knockout cell lines. Researchers use these antibodies to explore PEBP4’s role in disease mechanisms, biomarker discovery, and its interplay with oncogenic signaling networks. However, cross-reactivity with other PEBP family members remains a challenge, necessitating rigorous validation for accurate experimental outcomes.
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