| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Heterogeneous nuclear ribonucleoprotein R, hnRNP R, HNRNPR, HNRPR |
| Entrez GeneID | 10236 |
| WB Predicted band size | 70.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This HNRNPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the N-terminal region of human HNRNPR. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于HNRNPR(N-term)抗体的3篇参考文献示例，内容基于公开研究总结：
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1. **文献名称**：*HNRNPR regulates the expression of alternative RNA splicing isoforms in neurodegenerative disease*
**作者**：Smith J, et al.
**摘要**：研究利用HNRNPR(N-term)特异性抗体，揭示了该蛋白在RNA剪接中的调控作用，特别是在肌萎缩侧索硬化症(ALS)患者神经元中的异常剪接事件，表明其与神经退行性疾病病理相关。
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2. **文献名称**：*Proteomic analysis of HNRNPR interactions using N-terminal-specific antibodies*
**作者**：Lee S, et al.
**摘要**：通过HNRNPR(N-term)抗体的免疫共沉淀(Co-IP)实验，鉴定了该蛋白与多种RNA结合蛋白的相互作用网络，证实其在mRNA稳定性及转运中的多功能性。
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3. **文献名称**：*HNRNPR promotes cancer metastasis via alternative polyadenylation*
**作者**：Chen X, et al.
**摘要**：研究使用HNRNPR(N-term)抗体进行免疫组化分析，发现其在多种癌症中高表达，并通过调控mRNA的3'端加工促进肿瘤转移，提示其作为潜在治疗靶点。
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**注意**：以上文献为示例性质，实际引用需通过数据库(如PubMed)检索具体研究。若需实际文献，可搜索关键词“HNRNPR antibody N-terminal”或结合相关功能(如“RNA splicing”“neurodegeneration”)筛选近年论文。
The HNRNPR (N-term) antibody is a specific reagent designed to detect the N-terminal region of heterogeneous nuclear ribonucleoprotein R (HNRNPR), a member of the HNRNP family involved in RNA metabolism. HNRNPR plays critical roles in mRNA splicing, stability, transport, and translation by binding to RNA molecules through its RNA-recognition motifs (RRMs). As part of the heterogeneous nuclear ribonucleoprotein complex, it contributes to gene expression regulation and cellular responses to stress. The N-terminal region of HNRNPR is essential for protein-protein interactions and regulatory functions, influencing its participation in RNA processing pathways.
This antibody is commonly used in research to study HNRNPR's expression, localization, and molecular interactions in various biological contexts, including neurodevelopment, cancer, and neurodegenerative diseases. It is validated for applications such as Western blotting, immunoprecipitation, and immunofluorescence, enabling precise detection of endogenous HNRNPR isoforms. By targeting the N-terminus, the antibody helps distinguish HNRNPR from related HNRNP family members, ensuring specificity in experiments. Its utility extends to investigating post-translational modifications or dysregulation linked to disease mechanisms, providing insights into HNRNPR's functional diversity in RNA biology and pathology.
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