首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal PJA2 Antibody

  • 中文名: PJA2抗体
  • 别    名: E3 ubiquitin-protein ligase Praja-2, Praja2, 632-, RING finger protein 131, PJA2, KIAA0438, RNF131
货号: IPDX31757
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesE3 ubiquitin-protein ligase Praja-2, Praja2, 632-, RING finger protein 131, PJA2, KIAA0438, RNF131
Entrez GeneID9867
WB Predicted band size78.2kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PJA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-311 amino acids from the Central region of human PJA2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

+ +

参考文献

以下是3条与PJA2抗体相关的参考文献示例(内容基于假设性文献整理):

1. **文献名称**:*PJA2 regulates Tau stability via ubiquitination in Alzheimer's disease models*

**作者**:Smith A, et al.

**摘要**:研究揭示了E3泛素连接酶PJA2通过泛素化修饰调控Tau蛋白降解的机制。利用特异性PJA2抗体进行免疫共沉淀实验,证实PJA2与Tau直接相互作用,促进其泛素化依赖的蛋白酶体降解,可能影响阿尔茨海默病病理进展。

2. **文献名称**:*Role of PJA2 in EGFR signaling and glioblastoma progression*

**作者**:Zhang Y, et al.

**摘要**:通过Western blot和免疫荧光技术(使用PJA2抗体),研究发现PJA2在胶质母细胞瘤中高表达,并通过泛素化修饰调控EGFR蛋白稳定性,促进肿瘤细胞增殖和侵袭,为靶向治疗提供潜在靶点。

3. **文献名称**:*Structural and functional analysis of PJA2 ubiquitin ligase*

**作者**:Chen L, et al.

**摘要**:本研究解析了PJA2蛋白的晶体结构,并利用抗体筛选验证其底物结合域。实验表明PJA2通过特定的环指结构域招募泛素化底物,参与细胞周期调控和凋亡信号通路。

注:以上文献为示例性质,实际引用需查询具体数据库(如PubMed)获取真实文献。

背景信息

The PJA2 antibody targets the protein Praja-2 (PJA2), a member of the E3 ubiquitin ligase family, which plays a critical role in regulating protein turnover via the ubiquitin-proteasome system. PJA2 contains a conserved RING-H2 domain at its N-terminus, enabling its enzymatic activity, and a PHR (PAM, HIGHwire, and RPM-1) domain at the C-terminus, involved in substrate recognition. It mediates ubiquitination of substrates like Smad proteins, influencing signaling pathways such as TGF-β/BMP and neuronal development. PJA2 is implicated in diverse cellular processes, including cell cycle progression, apoptosis, and synaptic plasticity. Dysregulation of PJA2 has been linked to cancers, neurodegenerative disorders, and cardiovascular diseases, highlighting its potential as a therapeutic or diagnostic target. The PJA2 antibody is widely used in research to detect PJA2 expression levels, study its interaction partners, and explore its role in disease mechanisms through techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Its development has advanced understanding of ubiquitin-dependent regulatory networks and their impact on cellular homeostasis.

客户数据及评论

折叠内容

大包装询价

×