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Rabbit Polyclonal ZP3 Antibody

  • 中文名： ZP3抗体
  • 别    名： Zona pellucida sperm-binding protein 3, Sperm receptor, ZP3A/ZP3B, Zona pellucida glycoprotein 3, Zp-3, Zona pellucida protein C, Processed zona pellucida sperm-binding protein 3, ZP3, ZP3A, ZP3B, ZPC
货号: IPDX31759
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZona pellucida sperm-binding protein 3, Sperm receptor, ZP3A/ZP3B, Zona pellucida glycoprotein 3, Zp-3, Zona pellucida protein C, Processed zona pellucida sperm-binding protein 3, ZP3, ZP3A, ZP3B, ZPC
Entrez GeneID7784
WB Predicted band size47.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ZP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-380 amino acids from the C-terminal region of human ZP3.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ZP3抗体的3篇代表性文献及其摘要概述：

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1. **文献名称**: *Autoantibodies to ZP3 in women with premature ovarian insufficiency*

**作者**: Smith, S. et al.

**摘要**: 该研究探讨了ZP3抗体与卵巢早衰(POI)的关联，发现部分POI患者血清中存在高滴度的ZP3抗体，提示自身免疫反应可能通过靶向透明带蛋白破坏卵泡发育，导致卵巢功能衰退。

2. **文献名称**: *ZP3 peptide-based contraceptive vaccines: immunogenicity and fertility effects in animal models*

**作者**: Gupta, S.K. & Bansal, P.

**摘要**: 研究评估了基于ZP3多肽的避孕疫苗在小鼠模型中的效果，发现接种后诱导的抗体能特异性结合透明带，显著降低受精率，但部分个体出现卵巢炎症反应，提示潜在免疫副作用。

3. **文献名称**: *Role of anti-ZP3 antibodies in infertility: diagnostic and therapeutic implications*

**作者**: Zhang, Y. et al.

**摘要**: 通过临床样本分析，该文献提出ZP3抗体可作为不明原因不孕症的潜在生物标志物，并探索了免疫调节疗法降低抗体滴度后患者妊娠率的改善情况。

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**注**：以上文献信息为示例性概括，实际文献需通过PubMed、Google Scholar等平台检索确认具体标题及作者。如需全文，建议使用关键词“ZP3 antibody”、“infertility”、“contraceptive vaccine”结合数据库进一步查找。

背景信息

ZP3 (zona pellucida glycoprotein 3) is a critical component of the zona pellucida, an extracellular matrix surrounding mammalian oocytes. It plays a vital role in species-specific sperm-egg binding and fertilization by interacting with sperm surface receptors. ZP3 antibodies are autoantibodies targeting this glycoprotein, often implicated in immune-mediated infertility. In women, anti-ZP3 antibodies may disrupt folliculogenesis, impair oocyte quality, or block sperm binding, leading to reduced fertility or sterility. Their presence is associated with conditions like premature ovarian insufficiency (POI) and unexplained infertility. In men, such antibodies might arise due to immune reactions against sperm antigens cross-reactive with ZP3. Research also explores ZP3 antibodies in contraceptive vaccine development, leveraging their ability to inhibit fertilization. However, their pathogenic role remains complex, as ZP3 antibodies are occasionally detected in fertile individuals, suggesting variable clinical significance. Diagnostic tests (e.g., ELISA) help identify these antibodies in serum or follicular fluid, though standardization challenges persist. Studies in animal models, particularly mice, have clarified ZP3's immunogenicity and antibody-mediated interference in reproduction, informing both fertility treatments and immunocontraceptive strategies.

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