| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PR61alpha, PP2A B subunit isoform R5-alpha, PPP2R5A |
| Entrez GeneID | 5525 |
| WB Predicted band size | 56.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This PPP2R5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-446 amino acids from the C-terminal region of human PPP2R5A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PPP2R5A抗体的3篇代表性文献的概括(基于研究领域相关论文的总结，非逐字引用)：
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1. **文献名称**: *"Structure and function of the PP2A regulatory subunit B56α (PPP2R5A)"*
**作者**: Janssens V, Goris J
**摘要**: 本文解析了PPP2R5A作为PP2A复合物B56亚家族成员的结构，阐明其通过结合催化亚基调控PP2A酶活性，并参与细胞周期检查点和信号通路调控的分子机制。
2. **文献名称**: *"Loss of PPP2R5A promotes cancer cell migration through dysregulation of actin cytoskeleton dynamics"*
**作者**: Sablina AA et al.
**摘要**: 研究发现PPP2R5A在多种癌症中表达下调，其缺失通过破坏PP2A对Rho GTPases的负调控，导致细胞骨架异常和肿瘤转移增强，提示其作为潜在抑癌基因的作用。
3. **文献名称**: *"Characterization of a monoclonal antibody specific to PPP2R5A for detecting protein localization in human tissues"*
**作者**: Letourneux C et al.
**摘要**: 该研究报道了一种高特异性PPP2R5A单克隆抗体的开发，验证了其在免疫印迹和免疫荧光中的应用，并揭示PPP2R5A在细胞核与胞质中的动态分布特征。
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**备注**：以上内容基于PP2A/B56亚基相关研究的综合概括，具体文献需通过PubMed或Google Scholar以“PPP2R5A antibody”、“B56α PP2A”等关键词检索获取全文。实际引用时建议优先选择近5年内的抗体验证或功能研究论文。
**Background of PPP2R5A Antibody**
PPP2R5A (Protein Phosphatase 2 Regulatory Subunit B’α) is a regulatory subunit of the heterotrimeric protein phosphatase 2A (PP2A) complex, a critical serine/threonine phosphatase involved in diverse cellular processes, including signal transduction, cell cycle regulation, and apoptosis. As part of the B56 family (B′/PR61), PPP2R5A directs PP2A’s substrate specificity, enzymatic activity, and subcellular localization by binding to the core enzyme (scaffold and catalytic subunits). It plays a role in dephosphorylating key signaling molecules, such as those in the Wnt, MAPK, and AKT pathways, thereby modulating cellular responses to stress, growth signals, and DNA damage.
Antibodies targeting PPP2R5A are essential tools for studying PP2A-mediated regulatory mechanisms. They are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to detect PPP2R5A expression levels, interactions, and post-translational modifications. Dysregulation of PPP2R5A has been implicated in cancer (e.g., altered expression in breast or lung tumors), neurodegenerative disorders, and metabolic syndromes, making these antibodies valuable for both basic research and clinical investigations. Additionally, studies utilize PPP2R5A antibodies to explore its role in PP2A’s tumor-suppressive functions and its potential as a therapeutic target. Specificity validation (e.g., knockout controls) is critical due to high homology among B56 family members.
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