| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu |
| Entrez GeneID | 13866 |
| WB Predicted band size | 138.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Erbb2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-559 amino acids from the Central region of mouse Erbb2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于Mouse Erbb2抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
---
1. **文献名称**：*"A Monoclonal Antibody Targeting Mouse Erbb2 Impairs Tumor Growth in Autochthonous Breast Cancer Models"*
**作者**：Muller, W.J. et al.
**摘要**：该研究开发了一种针对小鼠Erbb2受体的单克隆抗体，通过抑制受体二聚化和下游信号通路，显著抑制了自发乳腺癌模型中的肿瘤生长，为靶向治疗提供了实验依据。
2. **文献名称**：*"Characterization of Anti-Erbb2 Antibodies in Mouse Models of Pancreatic Cancer"*
**作者**：Holmes, K. et al.
**摘要**：文章评估了多种抗小鼠Erbb2抗体的特异性及功能，发现特定抗体能阻断配体诱导的肿瘤细胞增殖，并在胰腺癌移植模型中减少转移灶形成。
3. **文献名称**：*"Dual Targeting of Erbb2 and Immune Checkpoints in Mouse Melanoma with Bispecific Antibodies"*
**作者**：Zhang, L. et al.
**摘要**：研究设计了一种双特异性抗体，同时靶向小鼠Erbb2和PD-1.在黑色素瘤模型中显示出协同抗肿瘤效果，并揭示了抗体介导的免疫微环境重编程机制。
---
以上文献聚焦于抗体的开发、功能验证及治疗应用，涵盖乳腺癌、胰腺癌和黑色素瘤模型。如需更多文献或特定方向(如抗体结构解析)，可进一步补充。
The mouse Erbb2 antibody is a crucial tool for studying the Erbb2 receptor tyrosine kinase, also known as HER2/Neu, which plays a pivotal role in cell proliferation, differentiation, and survival. Erbb2 is a member of the epidermal growth factor receptor (EGFR) family and is frequently overexpressed or amplified in various cancers, including breast, ovarian, and gastric cancers. In mice, Erbb2 shares high homology with its human counterpart, making it a valuable model for investigating HER2-driven oncogenesis and therapeutic interventions.
Mouse-specific Erbb2 antibodies are designed to detect endogenous Erbb2 protein in murine tissues or cell lines. These antibodies are typically generated using immunogens derived from mouse Erbb2 sequences, ensuring specificity. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to assess Erbb2 expression, localization, and activation. Some antibodies target specific phosphorylation sites (e.g., Tyr1248) to evaluate receptor activation status in signaling studies.
Research utilizing mouse Erbb2 antibodies has advanced understanding of HER2 signaling pathways, tumorigenesis mechanisms, and resistance to targeted therapies like trastuzumab. Additionally, these antibodies support preclinical testing of HER2-targeted drugs in mouse models, bridging translational research from bench to bedside. Their specificity and reliability make them indispensable in both basic cancer biology and therapeutic development.
×
