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Rabbit Polyclonal CALCA/CT Antibody

  • 中文名: CALCA/CT抗体
  • 别    名: Calcitonin, Calcitonin, Katacalcin, Calcitonin carboxyl-terminal peptide, CCP, PDN-21, CALCA, CALC1
货号: IPDX31561
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCalcitonin, Calcitonin, Katacalcin, Calcitonin carboxyl-terminal peptide, CCP, PDN-21, CALCA, CALC1
Entrez GeneID796
WB Predicted band size15.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis CALCA/CT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-132 amino acids from the C-terminal region of human CALCA/CT.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于CALCA/CT抗体的示例性参考文献(仅供参考,实际文献需通过学术数据库查询):

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1. **《Immunohistochemical detection of calcitonin in medullary thyroid carcinoma》**

- **作者**: Kaserer K, et al.

- **摘要**: 该研究验证了抗人降钙素(CT)单克隆抗体在甲状腺髓样癌(MTC)诊断中的应用,证明其高特异性及敏感性,可作为MTC病理分型的可靠标志物。

2. **《Role of calcitonin gene-related peptide (CGRP) and calcitonin antibodies in bone metabolism studies》**

- **作者**: Villa I, et al.

- **摘要**: 通过开发针对CALCA基因产物(CGRP和降钙素)的多克隆抗体,探讨二者在骨质疏松模型中的调控作用,揭示其在骨代谢中的双重功能。

3. **《Development and validation of a radioimmunoassay for human calcitonin》**

- **作者**: Bucht E, et al.

- **摘要**: 研究描述了一种高灵敏度的放射免疫分析法,利用兔源多克隆CT抗体检测血清降钙素水平,为甲状腺功能异常疾病的早期诊断提供技术支持。

4. **《Calcitonin antibody-based detection in inflammatory pain models》**

- **作者**: Assadi F, et al.

- **摘要**: 利用抗CT抗体研究降钙素在慢性炎症疼痛模型中的表达变化,发现其与痛觉敏化相关,为镇痛靶点开发提供依据。

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**注意**:以上为示例文献,实际引用时请通过PubMed、Web of Science等平台检索真实文献并核对详细信息。

背景信息

The CALCA gene encodes calcitonin (CT) and calcitonin gene-related peptide (CGRP), two critical neuropeptides derived from alternative RNA splicing. CT is a 32-amino-acid hormone primarily produced by thyroid C-cells, involved in calcium homeostasis and bone metabolism. CGRP, a 37-amino-acid peptide, functions as a potent vasodilator and neurotransmitter, playing roles in pain signaling, migraine pathophysiology, and cardiovascular regulation. Antibodies targeting CALCA/CT are essential tools in research and diagnostics. In clinical settings, CT-specific antibodies are widely used to detect medullary thyroid carcinoma (MTC), a tumor of thyroid C-cells that overexpresses CT. Elevated CT levels, measured via immunoassays, serve as a diagnostic and prognostic biomarker for MTC. In research, CALCA/CT antibodies help map peptide distribution in tissues, study secretory mechanisms, and explore therapeutic targets for conditions like migraine (CGRP inhibitors are now FDA-approved treatments). These antibodies are typically generated using synthetic peptide fragments or recombinant proteins, validated for specificity in techniques such as immunohistochemistry, ELISA, and Western blot. Cross-reactivity between CT and CGRP is a key consideration during antibody development due to their shared genetic origin. Recent advancements include monoclonal antibodies with high selectivity, enhancing diagnostic accuracy and enabling targeted therapies.

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