| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glycine receptor subunit beta, Glycine receptor 58 kDa subunit, GLRB |
| Entrez GeneID | 2743 |
| WB Predicted band size | 56.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GLRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-132 amino acids from the N-terminal region of human GLRB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及GLRB(N-term)抗体的文献摘要信息，供参考：
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1. **文献名称**：*Glycine receptor β-subunit regulates hippocampal synaptic plasticity*
**作者**：Smith A, et al. (2018)
**摘要**：本研究利用GLRB N端特异性抗体，在小鼠海马神经元中验证了甘氨酸受体β亚基(GLRB)在突触可塑性中的调控作用。通过免疫印迹和免疫组化发现，GLRB在抑制性突触中富集，其缺失导致长时程增强(LTP)异常，提示GLRB对神经信号传导的关键影响。
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2. **文献名称**：*Antibody-based detection of N-terminal glycine receptor β isoforms in human brain tissue*
**作者**：Chen L, et al. (2020)
**摘要**：文章开发了一种针对GLRB N端表位的单克隆抗体，用于区分不同剪接变体在人类大脑皮层中的表达。通过免疫沉淀和质谱分析，证实该抗体特异性识别GLRB的N端结构域，并发现其在自闭症患者脑组织中表达下调的潜在关联。
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3. **文献名称**：*GLRB mutations alter inhibitory neurotransmission in hyperekplexia: Insights from antibody-mediated protein localization*
**作者**：Rodriguez E, et al. (2019)
**摘要**：研究利用GLRB N端抗体定位突变体蛋白在患者细胞模型中的表达，发现甘氨酸受体β亚基的N端结构域突变导致细胞膜表面受体减少，从而引发过度惊跳症(hyperekplexia)的病理机制，为靶向治疗提供了依据。
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**注**：以上文献为示例性内容，实际文献需通过PubMed或Web of Science等平台检索关键词如“GLRB antibody N-terminal”或“Glycine Receptor Beta epitope mapping”获取。建议结合具体研究需求筛选近年高引论文。
The GLRB (N-term) antibody is designed to target the N-terminal region of the glycine receptor beta subunit (GLRB), a critical component of inhibitory neurotransmitter systems in the central nervous system. Glycine receptors are ligand-gated ion channels that mediate fast synaptic inhibition, primarily in the spinal cord, brainstem, and retinal neurons. Composed of alpha (α) and beta (β) subunits, these receptors regulate motor coordination, sensory processing, and reflex pathways. The β-subunit (encoded by GLRB) plays a structural role in receptor assembly, anchoring the receptor to the postsynaptic membrane via interactions with gephyrin, and modulates receptor kinetics and pharmacology.
Mutations in GLRB are linked to hyperekplexia (startle disease), a rare neurological disorder characterized by exaggerated startle responses and muscle rigidity. The GLRB (N-term) antibody is widely used in research to investigate receptor expression, localization, and dysfunction in disease models. It is employed in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study receptor distribution in neural tissues, protein-protein interactions, and the impact of genetic variants. This antibody aids in elucidating mechanisms underlying glycinergic neurotransmission and developing therapeutic strategies for glycinergic pathway-related disorders.
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