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Rabbit Polyclonal DVL2 Antibody

  • 中文名: DVL2抗体
  • 别    名: Segment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2, DVL2
货号: IPDX31553
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesSegment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2, DVL2
Entrez GeneID1856
WB Predicted band size78.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis DVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-617 amino acids from the C-terminal region of human DVL2.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于DVL2抗体的模拟参考文献(基于公开领域知识框架构建,具体文献需通过学术数据库核实):

1. **《DVL2-mediated Wnt/β-catenin signaling suppression inhibits colorectal cancer metastasis》**

- 作者:Chen, L. et al.

- 摘要:研究利用DVL2特异性抗体阻断Wnt信号通路,发现抑制DVL2可降低β-catenin核转位,从而抑制结直肠癌细胞的迁移和侵袭能力。

2. **《Antibody-based targeting of DVL2 disrupts planar cell polarity in developmental models》**

- 作者:Smith, J.R. & Yamaguchi, T.

- 摘要:通过DVL2抗体的显微注射实验,证明DVL2在胚胎发育中调控细胞极性和组织形态发生,抗体干预导致斑马鱼模型体轴发育异常。

3. **《DVL2 phosphorylation status as a biomarker for Wnt pathway activation in triple-negative breast cancer》**

- 作者:Gupta, S. et al.

- 摘要:开发新型DVL2磷酸化位点特异性抗体,证实其在三阴性乳腺癌中可作为Wnt通路异常激活的生物标志物,与患者预后显著相关。

注:以上为基于DVL2已知功能的模拟参考文献框架,实际文献需通过PubMed/Google Scholar以"DVL2 antibody"+"具体研究领域"为关键词检索获取。建议优先选择近五年内发表的、经同行评审的研究论文。

背景信息

The DVL2 antibody is a crucial tool in studying the Dishevelled (DVL) protein family, which plays a central role in Wnt signaling pathways. DVL2. one of three mammalian Dishevelled paralogs (DVL1-3), acts as a scaffold protein mediating both canonical (β-catenin-dependent) and non-canonical Wnt signaling. These pathways regulate critical biological processes, including embryonic development, cell polarity, proliferation, and tissue homeostasis. Antibodies targeting DVL2 enable researchers to detect, quantify, and localize the protein in various experimental settings, such as Western blotting, immunohistochemistry, and immunofluorescence. Given DVL2's involvement in cancer (e.g., colorectal, breast) and developmental disorders, the antibody is particularly valuable for investigating disease mechanisms and Wnt pathway dysregulation. Many commercial DVL2 antibodies are raised against conserved regions, though specificity validation across paralogs is essential due to high sequence homology. Applications extend to studying post-translational modifications, protein-protein interactions, and subcellular distribution patterns critical for DVL2's function in signal transduction. Proper controls, including knockout cell lines, are recommended to confirm antibody specificity in experimental models.

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